Psychostimulants influence oxidative stress and redox signatures: the role of DNA methylation.

IF 5.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Redox Report Pub Date : 2022-12-01 DOI:10.1080/13510002.2022.2043224
Vaishnavi Sundar, Tamizhselvi Ramasamy, Mayur Doke, Thangavel Samikkannu
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Abstract

Objective: Psychostimulant use induces oxidative stress and alters redox imbalance, influencing epigenetic signatures in the central nervous system (CNS). Among the various epigenetic changes, DNA methylation is directly linked to oxidative stress metabolism via critical redox intermediates such as NAD+, S-adenosylmethionine (SAM), and 2-oxoglutarate. Fluctuations in these intermediates directly influence epigenetic signatures, which leads to detectable alterations in gene expression and protein modification. This review focuses on recent advances in the impact of psychostimulant use on redox-imbalance-induced DNA methylation to develop novel epigenetics-based early interventions. Methods: This review is based on collective research data obtained from the PubMed, Science Direct, and Medline databases. The keywords used in the electronic search in these databases were redox, substance use disorder, psychostimulants, DNA methylation, and neurological diseases. Results: Instability in DNA methylation levels and redox expression effects are reported in various behavioral models stimulated by psychostimulants and opioids, indicating the widespread involvement of epigenetic changes in DNA methylation signatures in neurological disorders. Discussion: This review summarizes the need for more studies and experimental evaluations of DNA-methylation-based strategies that may help to understand the association between psychostimulant use and oxidative stress or redox-linked metabolic recalibration influencing neuronal impairments.

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精神兴奋剂影响氧化应激和氧化还原特征:DNA甲基化的作用。
目的:精神兴奋剂的使用诱导氧化应激并改变氧化还原失衡,影响中枢神经系统(CNS)的表观遗传学特征。在各种表观遗传学变化中,DNA甲基化通过关键的氧化还原中间体如NAD+、S-腺苷甲硫氨酸(SAM)和2-氧戊二酸与氧化应激代谢直接相关。这些中间体的波动直接影响表观遗传学特征,从而导致基因表达和蛋白质修饰的可检测变化。这篇综述的重点是使用精神刺激剂对氧化还原失衡诱导的DNA甲基化的影响的最新进展,以开发新的基于表观遗传学的早期干预措施。方法:本综述基于从PubMed、Science Direct和Medline数据库获得的集体研究数据。在这些数据库的电子搜索中使用的关键词是氧化还原、物质使用障碍、精神刺激剂、DNA甲基化和神经疾病。结果:据报道,在精神刺激剂和阿片类药物刺激的各种行为模型中,DNA甲基化水平和氧化还原表达效应不稳定,这表明DNA甲基化特征的表观遗传学变化广泛参与神经疾病。讨论:这篇综述总结了对基于DNA甲基化的策略进行更多研究和实验评估的必要性,这可能有助于理解精神刺激剂的使用与影响神经元损伤的氧化应激或氧化还原相关代谢重新校准之间的关联。
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来源期刊
Redox Report
Redox Report 生物-生化与分子生物学
CiteScore
6.10
自引率
0.00%
发文量
28
审稿时长
>12 weeks
期刊介绍: Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.
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