The regulatory effects of the apelin/APJ system on depression: A prospective therapeutic target

IF 2.5 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Neuropeptides Pub Date : 2023-09-11 DOI:10.1016/j.npep.2023.102382

Yanjun Tian , Ruihao Wang , Lin Liu , Wenhuan Zhang , Haiqing Liu , Liqing Jiang , Yunlu Jiang

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Abstract

Depression is a debilitating neuropsychological disorder characterized by high incidence, high recurrence, high suicide, and high disability rates, which poses serious threats to human health and imposes heavy psychological and economic burdens on family and society. The pathogenesis of depression is extremely complex, and its etiology is multifactorial. Mounting evidence suggests that apelin and apelin receptor APJ, which compose the apelin/APJ system, are related to the development of depression. However, the specific mechanism is still unclear, and research in this area in human is still insufficient. Acceleration of research into the regulatory effects and underlying mechanisms of the apelin/APJ system in depression may identify attractive therapeutic targets and contribute to the development of novel intervention strategies against this devastating psychological disorder. In this review, we mainly discuss the regulatory effects of apelin/APJ system on depression and its potential therapeutic applications.

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APJ系统对抑郁症的调控作用:一个前瞻性的治疗靶点

抑郁症是一种使人衰弱的神经心理障碍，其特点是发病率高、复发率高、自杀率高、致残率高，对人类健康构成严重威胁，并给家庭和社会带来沉重的心理和经济负担。抑郁症的发病机制极其复杂，其病因是多因素的。越来越多的证据表明，组成apelin/APJ系统的apelin和apelin受体APJ与抑郁症的发展有关。然而，具体的机制尚不清楚，在人类中这一领域的研究仍然不足。加速对apelin/APJ系统在抑郁症中的调节作用和潜在机制的研究，可能会确定有吸引力的治疗靶点，并有助于开发针对这种毁灭性心理障碍的新干预策略。在这篇综述中，我们主要讨论apelin/APJ系统对抑郁症的调节作用及其潜在的治疗应用。

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来源期刊

Neuropeptides 医学-内分泌学与代谢

CiteScore

5.40

自引率

6.90%

发文量

审稿时长

>12 weeks

期刊介绍： The aim of Neuropeptides is the rapid publication of original research and review articles, dealing with the structure, distribution, actions and functions of peptides in the central and peripheral nervous systems. The explosion of research activity in this field has led to the identification of numerous naturally occurring endogenous peptides which act as neurotransmitters, neuromodulators, or trophic factors, to mediate nervous system functions. Increasing numbers of non-peptide ligands of neuropeptide receptors have been developed, which act as agonists or antagonists in peptidergic systems. The journal provides a unique opportunity of integrating the many disciplines involved in all neuropeptide research. The journal publishes articles on all aspects of the neuropeptide field, with particular emphasis on gene regulation of peptide expression, peptide receptor subtypes, transgenic and knockout mice with mutations in genes for neuropeptides and peptide receptors, neuroanatomy, physiology, behaviour, neurotrophic factors, preclinical drug evaluation, clinical studies, and clinical trials.