Hannah J Brown, Ali M Baird, Sarah Khalife, Pedro Escobedo, Peter Filip, Peter Papagiannopoulos, Paolo Gattuso, Pete Batra, Bobby A Tajudeen
{"title":"Histopathological Differences in Adult and Elderly Patients With Chronic Rhinosinusitis.","authors":"Hannah J Brown, Ali M Baird, Sarah Khalife, Pedro Escobedo, Peter Filip, Peter Papagiannopoulos, Paolo Gattuso, Pete Batra, Bobby A Tajudeen","doi":"10.1177/19458924231172078","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Adult and elderly patients with chronic rhinosinusitis (CRS) undergo similar therapeutic management. Few studies have undertaken sinonasal tissue-level comparisons of these groups. This study examines histopathological differences between adults (>18, <65 years) and the elderly (≥65 years) with CRS, with the goal of optimizing medical management.</p><p><strong>Methods: </strong>In a retrospective cohort analysis, demographic factors, comorbidities, and a structured histopathological report of 13 variables were compared across adult and elderly patients with CRS who underwent functional endoscopic sinus surgery. These cohorts of adult and elderly patients included patients with and without nasal polyps (NP).</p><p><strong>Results: </strong>Three hundred adult (158 aCRSsNP, 142 aCRSwNP) and 77 elderly (38 eCRSsNP, 39 eCRSwNP) patients were analyzed. Mean age of the adult cohort was 44.4 ± 12.4 years, while that of the elderly cohort was 71.9 ± 5.9 years (<i>P</i> <i><</i> <i>.001</i>). Significantly more adults compared to elderly individuals demonstrated a positive atopic status (79.7% vs 64.0%, <i>P</i> <i>=</i> <i>.004</i>). Elderly patients exhibited higher rates of comorbid diabetes mellitus than adult patients (21.6% vs 10.3%, <i>P</i> <i>=</i> <i>.009</i>). Adults exhibited more tissue eosinophilia (43.4% vs 28.6%, <i>P</i> <i>=</i> <i>.012</i>) and presence of eosinophil aggregates (25.0% vs 14.3%, <i>P</i> <i>=</i> <i>.029</i>) compared to elderly patients, regardless of NP status. Conversely, the elderly demonstrated significantly more fungal elements (11.7% vs 3.0%, <i>P</i> <i>=</i> <i>.004</i>), and trended toward increased overall inflammation (63.6% vs 55.3%, <i>P</i> <i>=</i> <i>.118</i>) and tissue neutrophilia (35.1% vs 27.3%, <i>P</i> <i>=</i> <i>.117</i>), compared to adults.</p><p><strong>Conclusion: </strong>Sinonasal tissue of adult and elderly patients with CRS demonstrates clear histopathological differences. Patient comorbidities, in addition to histopathological characterizations, may provide further context for management optimization.</p><p><strong>Level of evidence: </strong>2.</p><p><strong>Short summary: </strong>Sinonasal tissue samples from adult and elderly patients with CRS demonstrate clear histopathological differences. These patient populations also exhibit unique comorbidities. These distinctions have the potential to inform and optimize management of this condition.</p>","PeriodicalId":7650,"journal":{"name":"American Journal of Rhinology & Allergy","volume":"37 5","pages":"518-523"},"PeriodicalIF":2.5000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Rhinology & Allergy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/19458924231172078","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OTORHINOLARYNGOLOGY","Score":null,"Total":0}
引用次数: 2
Abstract
Background: Adult and elderly patients with chronic rhinosinusitis (CRS) undergo similar therapeutic management. Few studies have undertaken sinonasal tissue-level comparisons of these groups. This study examines histopathological differences between adults (>18, <65 years) and the elderly (≥65 years) with CRS, with the goal of optimizing medical management.
Methods: In a retrospective cohort analysis, demographic factors, comorbidities, and a structured histopathological report of 13 variables were compared across adult and elderly patients with CRS who underwent functional endoscopic sinus surgery. These cohorts of adult and elderly patients included patients with and without nasal polyps (NP).
Results: Three hundred adult (158 aCRSsNP, 142 aCRSwNP) and 77 elderly (38 eCRSsNP, 39 eCRSwNP) patients were analyzed. Mean age of the adult cohort was 44.4 ± 12.4 years, while that of the elderly cohort was 71.9 ± 5.9 years (P<.001). Significantly more adults compared to elderly individuals demonstrated a positive atopic status (79.7% vs 64.0%, P=.004). Elderly patients exhibited higher rates of comorbid diabetes mellitus than adult patients (21.6% vs 10.3%, P=.009). Adults exhibited more tissue eosinophilia (43.4% vs 28.6%, P=.012) and presence of eosinophil aggregates (25.0% vs 14.3%, P=.029) compared to elderly patients, regardless of NP status. Conversely, the elderly demonstrated significantly more fungal elements (11.7% vs 3.0%, P=.004), and trended toward increased overall inflammation (63.6% vs 55.3%, P=.118) and tissue neutrophilia (35.1% vs 27.3%, P=.117), compared to adults.
Conclusion: Sinonasal tissue of adult and elderly patients with CRS demonstrates clear histopathological differences. Patient comorbidities, in addition to histopathological characterizations, may provide further context for management optimization.
Level of evidence: 2.
Short summary: Sinonasal tissue samples from adult and elderly patients with CRS demonstrate clear histopathological differences. These patient populations also exhibit unique comorbidities. These distinctions have the potential to inform and optimize management of this condition.
期刊介绍：
The American Journal of Rhinology & Allergy is a peer-reviewed, scientific publication committed to expanding knowledge and publishing the best clinical and basic research within the fields of Rhinology & Allergy. Its focus is to publish information which contributes to improved quality of care for patients with nasal and sinus disorders. Its primary readership consists of otolaryngologists, allergists, and plastic surgeons. Published material includes peer-reviewed original research, clinical trials, and review articles.
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