Is lysosomal acid lipase activity associated with the presence and severity of coronary artery disease?

IF 1.1 4区医学 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS Herz Pub Date : 2024-02-01 Epub Date: 2023-08-01 DOI:10.1007/s00059-023-05200-7

Emrullah Kızıltunç, Sabire Gökalp, Gürsel Biberoğlu, Yakup Yalçın, Burcu Cihan, Rıdvan M Öktem, Aslı İnci, Leyla Tümer, Mehmet R Yalçın, Adnan Abacı

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Abstract

Background: Lipid metabolism is considerably complex and there can be many critical steps in atherogenesis. The association between lysosomal acid lipase (LAL) activity and coronary artery disease (CAD) has not been elucidated in detail. We aimed to evaluate the association between LAL activity with the presence and severity of CAD in patients who are seen in daily clinical practice.

Methods: Patients who underwent coronary angiography were divided into groups according to the angiography results. Syntax scores and Gensini scores were calculated. The LAL activity was measured from dried blood spots.

Results: Median LAL activity values were similar in all study groups (normal coronary arteries: 0.40 nmol/punch/h; non-obstructive CAD: 0.44 nmol/punch/h; obstructive chronic CAD: 0.40 nmol/punch/h; obstructive acute coronary syndrome: 0.48 nmol/punch/h) and there was no correlation between coronary atherosclerotic burden and LAL activity (correlation coefficients Syntax score and LAL: -0.032; Gensini score and LAL: -0.030). In addition, no relationship between serum lipid levels and LAL activity was detected.

Conclusion: The presence of CAD and its severity is not associated with the LAL activity in patients encountered in daily clinical practice.

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溶酶体酸性脂肪酶活性与冠心病的存在和严重程度有关吗？

背景：脂质代谢相当复杂，动脉粥样硬化的发生可能有许多关键步骤。溶酶体酸性脂肪酶（LAL）活性与冠状动脉疾病（CAD）之间的关系尚未得到详细阐明。我们的目的是评估日常临床实践中患者的 LAL 活性与 CAD 的存在和严重程度之间的关系：方法：根据血管造影结果将接受冠状动脉造影术的患者分为几组。计算 Syntax 评分和 Gensini 评分。根据干血斑测量 LAL 活性：结果：所有研究组的 LAL 活性中位值相似（正常冠状动脉：0.40 nmol/pp-h）：结果：所有研究组的 LAL 活性中位值相似（正常冠状动脉：0.40 nmol/punch/h；非阻塞性 CAD：0.44 nmol/punch/h；阻塞性慢性 CAD：0.40 nmol/punch/h；阻塞性急性冠状动脉综合征：0.48 nmol/punch/h），冠状动脉粥样硬化负荷与 LAL 活性之间没有相关性（相关系数：Syntax 评分与 LAL：-0.032；Gensini 评分与 LAL：-0.030）。此外，未发现血清脂质水平与 LAL 活性之间存在任何关系：结论：在日常临床实践中，CAD 的存在及其严重程度与患者的 LAL 活性无关。

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来源期刊

Herz 医学-心血管系统

CiteScore

3.00

自引率

5.90%

发文量

审稿时长

4-8 weeks

期刊介绍： Herz is the high-level journal for further education for all physicians interested in cardiology. The individual issues of the journal each deal with specific topics and comprise review articles in English and German written by competent and esteemed authors. They provide up-to-date and comprehensive information concerning the speciality dealt with in the issue. Due to the fact that all relevant aspects of the pertinent topic of an issue are considered, an overview of the current status and progress in cardiology is presented. Reviews and original articles round off the spectrum of information provided.