Application of Thermoresponsive Smart Polymers based in situ Gel as a Novel Carrier for Tumor Targeting.

IF 2.3 4区医学 Q3 ONCOLOGY Current cancer drug targets Pub Date : 2024-01-01 DOI:10.2174/1568009623666230803111718

Nidhi Sudhir Dhote, Rajat Dineshbhai Patel, Utkarsha Kuwar, Mukta Agrawal, Amit Alexander, Parag Jain, Ajazuddin

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Abstract

The temperature-triggered in situ gelling system has been revolutionized by introducing an intelligent polymeric system. Temperature-triggered polymer solutions are initially in a sol state and then undergo a phase transition to form a gel at body temperature due to various parameters like pH, temperature, and so on. These smart polymers offer a number of advantages, including ease of administration, long duration of release of the drug, low administration frequency with good patient compliance, and targeted drug delivery with fewer adverse effects. Polymers such as poly(N-isopropylacrylamide) (PNIPAAm), polyethylene glycol (PEG), poly (N, N'-diethyl acrylamide), and polyoxypropylene (PPO) have been briefly discussed. In addition to various novel Drug Delivery Systems (DDS), the smart temperature-triggered polymeric system has various applications in cancer therapy and many other disease conditions. This review focuses on the principals involved in situ gelling systems using various temperature-triggered polymers for chemotherapeutic purposes, using smart DDS, and their advanced application in cancer therapy, as well as available marketed formulations and recent advances in these thermoresponsive sol-gel transforming systems.

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基于热致伸缩智能聚合物的原位凝胶作为新型载体在肿瘤靶向治疗中的应用。

通过引入智能聚合物系统，温度触发原位胶凝系统发生了革命性的变化。温度触发聚合物溶液最初处于溶胶状态，然后由于 pH 值、温度等各种参数的影响而发生相变，在体温下形成凝胶。这些智能聚合物具有许多优点，包括给药方便、药物释放持续时间长、给药频率低且患者依从性好、靶向给药且不良反应少。本文简要讨论了聚（N-异丙基丙烯酰胺）（PNIPAAm）、聚乙二醇（PEG）、聚（N，N'-二乙基丙烯酰胺）和聚氧丙烯（PPO）等聚合物。除了各种新型给药系统（DDS）外，智能温度触发聚合物系统在癌症治疗和许多其他疾病中也有各种应用。本综述重点介绍了利用各种温度触发聚合物原位胶凝系统进行化疗的原理、智能 DDS 及其在癌症治疗中的先进应用，以及这些热致伸缩性溶胶-凝胶转化系统的现有市场配方和最新进展。

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来源期刊

Current cancer drug targets 医学-肿瘤学

CiteScore

5.40

自引率

0.00%

发文量

105

审稿时长

1 months

期刊介绍： Current Cancer Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular drug targets involved in cancer, e.g. disease specific proteins, receptors, enzymes and genes. Current Cancer Drug Targets publishes original research articles, letters, reviews / mini-reviews, drug clinical trial studies and guest edited thematic issues written by leaders in the field covering a range of current topics on drug targets involved in cancer. As the discovery, identification, characterization and validation of novel human drug targets for anti-cancer drug discovery continues to grow; this journal has become essential reading for all pharmaceutical scientists involved in drug discovery and development.