Potential Utilisation of Secretome from Ascorbic Acid-Supplemented Stem Cells in Combating Skin Aging: Systematic Review of A Novel Idea.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-09-09 DOI:10.22074/cellj.2023.1995999.1253

Komang Ardi Wahyuningsih, Wimpie I Pangkahila, I Wayan Weta Weta, I Gde Raka Widiana, Ida Ayu Ika Wahyuniari

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Abstract

The secretome of stem cells consists of a spectrum of bioactive factors secreted by stem cells grown in culture mediacytokines, chemokines, and growth factors in addition to extracellular vesicles (exosomes and microvesicles). Ease of handling and storage of secretomes along with their bioactivity towards processes in skin aging and customizability makes them an appealing prospective therapy for skin aging. This systematic review aims to investigate the potential usage of ascorbic acid (AA)-supplemented stem cell secretomes (SCS) in managing skin aging. We extracted articles from three databases: PubMed, Scopus, and Cochrane. This review includes in vitro, in vivo, and clinical studies published in English that discuss the correlation of AA-supplemented-SCS with skin aging. We identified 1111 articles from database and non-database sources from which nine studies met the inclusion criteria. However, the study results were less specific due to the limited amount of available research that specifically assessed the effects of AAsupplemented SCS in skin aging. Although further studies are necessary, the AA modification of SCS is a promising potential for improving skin health.

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补充抗坏血酸的干细胞分泌组在对抗皮肤衰老中的潜在应用：一个新想法的系统综述。

干细胞的分泌组由培养基中生长的干细胞分泌的一系列生物活性因子、细胞因子、趋化因子和生长因子以及细胞外小泡（外泌体和微泡）组成。分泌体易于处理和储存，以及对皮肤衰老过程的生物活性和可定制性，使其成为一种有吸引力的皮肤衰老前瞻性疗法。本系统综述旨在研究抗坏血酸（AA）补充的干细胞分泌体（SCS）在管理皮肤衰老中的潜在用途。我们从PubMed、Scopus和Cochrane三个数据库中提取了文章。这篇综述包括以英文发表的体外、体内和临床研究，这些研究讨论了AA补充的SCS与皮肤衰老的相关性。我们从数据库和非数据库来源中鉴定了1111篇文章，其中9项研究符合纳入标准。然而，由于专门评估AA补充SCS对皮肤衰老影响的现有研究数量有限，研究结果不太具体。尽管还需要进一步的研究，但SCS的AA修饰在改善皮肤健康方面具有很好的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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