Anorectic effect of COR659 in a rat model of overeating.

IF 1.6 4区心理学 Q3 BEHAVIORAL SCIENCES Behavioural Pharmacology Pub Date : 2023-10-01 Epub Date: 2023-08-31 DOI:10.1097/FBP.0000000000000751

Paola Maccioni, Claudia Mugnaini, Mauro A M Carai, Gian Luigi Gessa, Federico Corelli, Giancarlo Colombo

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Abstract

COR659 is a new compound, the action of which is exerted via a dual mechanism: positive allosteric modulation of the GABAB receptor; antagonism or inverse agonism at the cannabinoid CB1 receptor. Recent lines of experimental evidence have indicated that COR659 potently and effectively reduced operant self-administration of and reinstatement of seeking behaviour for a chocolate-flavoured beverage. The present study was designed to assess whether the ability of COR659 to diminish these addictive-like, food-motivated behaviours extended to a rat model of overeating palatable food. To this end, rats were habituated to feed on a standard rat chow for 3 h/day; every 4 days, the 3-hour chow-feeding session was followed by a 1-hour feeding session with highly palatable, calorie-rich Danish butter cookies. Even though satiated, rats overconsumed cookies. COR659 (0, 2.5, 5, and 10 mg/kg, i.p.) was administered before the start of the cookie-feeding session. Treatment with all 3 doses of COR659 produced a substantial decrease in intake of cookies and calories from cookies. These results extend the anorectic profile of COR659 to overconsumption of a highly palatable food and intake of large amounts of unnecessary calories.

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COR659在大鼠暴饮模型中的厌食作用。

COR659是一种新化合物，其作用通过双重机制发挥：GABAB受体的正变构调节；对大麻素CB1受体的拮抗作用或反向激动作用。最近的实验证据表明，COR659有效有效地减少了巧克力口味饮料的操作性自我管理和寻求行为的恢复。本研究旨在评估COR659减少这些类似成瘾的、以食物为动机的行为的能力是否扩展到过量食用美味食物的大鼠模型中。为此，大鼠习惯于以标准大鼠食物喂养3天 h/天；每4天，在3小时的食物喂养之后，用美味可口、热量丰富的丹麦黄油饼干喂养1小时。尽管老鼠很饱，但它们还是过度食用饼干。COR659（0、2.5、5和10 mg/kg，i.p.）。所有3剂COR659的治疗都显著减少了饼干的摄入量和饼干中的热量。这些结果将COR659的厌食症特征扩展到过度食用高度可口的食物和摄入大量不必要的卡路里。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Pharmacology 医学-行为科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.