The DNA binding high mobility group box protein family functionally binds RNA.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY Wiley Interdisciplinary Reviews: RNA Pub Date : 2023-09-01 Epub Date: 2023-01-16 DOI:10.1002/wrna.1778
Desmond J Hamilton, Abigail E Hein, Deborah S Wuttke, Robert T Batey
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Abstract

Nucleic acid binding proteins regulate transcription, splicing, RNA stability, RNA localization, and translation, together tailoring gene expression in response to stimuli. Upon discovery, these proteins are typically classified as either DNA or RNA binding as defined by their in vivo functions; however, recent evidence suggests dual DNA and RNA binding by many of these proteins. High mobility group box (HMGB) proteins have a DNA binding HMGB domain, act as transcription factors and chromatin remodeling proteins, and are increasingly understood to interact with RNA as means to regulate gene expression. Herein, multiple layers of evidence that the HMGB family are dual DNA and RNA binding proteins is comprehensively reviewed. For example, HMGB proteins directly interact with RNA in vitro and in vivo, are localized to RNP granules involved in RNA processing, and their protein interactors are enriched in RNA binding proteins involved in RNA metabolism. Importantly, in cell-based systems, HMGB-RNA interactions facilitate protein-protein interactions, impact splicing outcomes, and modify HMGB protein genomic or cellular localization. Misregulation of these HMGB-RNA interactions are also likely involved in human disease. This review brings to light that as a family, HMGB proteins are likely to bind RNA which is essential to HMGB protein biology. This article is categorized under: RNA Interactions with Proteins and Other Molecules > Protein-RNA Recognition RNA Interactions with Proteins and Other Molecules > RNA-Protein Complexes RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications.

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DNA结合的高迁移率基团盒蛋白家族在功能上结合RNA。
核酸结合蛋白调节转录、剪接、RNA稳定性、RNA定位和翻译,共同调节对刺激的基因表达。一旦发现,这些蛋白质通常被分类为DNA或RNA结合,如其体内功能所定义的;然而,最近的证据表明,这些蛋白质中的许多具有双重DNA和RNA结合。高迁移率基团盒(HMGB)蛋白具有结合DNA的HMGB结构域,充当转录因子和染色质重塑蛋白,并且越来越被理解为与RNA相互作用,作为调节基因表达的手段。本文全面综述了HMGB家族是DNA和RNA双重结合蛋白的多层证据。例如,HMGB蛋白在体外和体内直接与RNA相互作用,定位于参与RNA加工的RNP颗粒,并且它们的蛋白质相互作用体富含参与RNA代谢的RNA结合蛋白。重要的是,在基于细胞的系统中,HMGB-RNA相互作用促进蛋白质-蛋白质相互作用,影响剪接结果,并改变HMGB蛋白质的基因组或细胞定位。HMGB-RNA相互作用的失调也可能与人类疾病有关。这篇综述揭示了作为一个家族,HMGB蛋白可能与RNA结合,这对HMGB蛋白生物学至关重要。本文分类为:RNA与蛋白质和其他分子的相互作用>蛋白质-RNA识别-RNA与蛋白质及其他分子的作用>RNA-蛋白质复合物-RNA与蛋白及其他分子相互作用>蛋白-RNA相互作用:功能含义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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