α-Synuclein Interactions in Mitochondria-ER Contacts: A Possible Role in Parkinson's Disease.

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2022-01-01 DOI:10.1177/25152564221119347

Adolfo Garcia Erustes, Gabriel Cicolin Guarache, Erika da Cruz Guedes, Anderson Henrique França Figueredo Leão, Gustavo José da Silva Pereira, Soraya Soubhi Smaili

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Abstract

Endoplasmic reticulum-mitochondria contact sites regulate various biological processes, such as mitochondrial dynamics, calcium homeostasis, autophagy and lipid metabolism. Notably, dysfunctions in these contact sites are closely related to neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis. However, details about the role of endoplasmic reticulum-mitochondria contact sites in neurodegenerative diseases remain unknown. In Parkinson's disease, interactions between α-synuclein in the contact sites and components of tether complexes that connect organelles can lead to various dysfunctions, especially with regards to calcium homeostasis. This review will summarize the main tether complexes present in endoplasmic reticulum-mitochondria contact sites, and their roles in calcium homeostasis and trafficking. We will discuss the impact of α-synuclein accumulation, its interaction with tethering complex components and the implications in Parkinson's disease pathology.

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α-突触核蛋白在线粒体-内质网接触中的相互作用:在帕金森病中的可能作用。

内质网-线粒体接触位点调节多种生物过程，如线粒体动力学、钙稳态、自噬和脂质代谢。值得注意的是，这些接触部位的功能障碍与神经退行性疾病密切相关，包括帕金森病、阿尔茨海默病和肌萎缩侧索硬化症。然而，关于内质网-线粒体接触部位在神经退行性疾病中的作用的细节仍然未知。在帕金森病中，接触部位α-突触核蛋白与连接细胞器的系链复合物组分之间的相互作用可导致各种功能障碍，特别是在钙稳态方面。本文将对存在于内质网-线粒体接触部位的系链复合物及其在钙稳态和转运中的作用进行综述。我们将讨论α-突触核蛋白积累的影响，它与系栓复合物组分的相互作用以及在帕金森病病理中的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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