Extending the Contacts Breaks the Flow.

Amado Carreras-Sureda, Christopher Henry, Nicolas Demaurex
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Abstract

In this news and views, we discuss our recent publication where we described how ER-PM membrane contact sites (MCS) are modulated during store operated calcium entry (SOCE). We also examine why enforcing ER-PM MCS by tethering proteins does not not enhance, but rather inhibits SOCE.

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在这篇新闻和观点中,我们讨论了我们最近发表的文章,其中我们描述了ER-PM膜接触位点(MCS)在储存操作钙进入(SOCE)过程中是如何被调节的。我们还研究了为什么通过捆绑蛋白质来加强ER-PM MCS不会增强,而是会抑制SOCE。
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