Detecting disability using self-reported and clinical assessments in early-stage relapsing-remitting multiple sclerosis: Looking for a complementary approach.

Susana Sainz de la Maza, Rocío Gómez-Ballesteros, Mónica Borges, Jesús Martín-Martínez, Javier Sotoca, Ana Alonso, Ana B Caminero, Laura Borrega, José L Sánchez-Menoyo, Francisco J Barrero-Hernández, Carmen Calles, Luis Brieva, María R Blasco-Quílez, Julio Dotor García-Soto, María Del Campo-Amigo, Laura Navarro-Cantó, Eduardo Agüera, Moisés Garcés-Redondo, Olga Carmona, Laura Gabaldón-Torres, Lucía Forero, Mariona Hervàs, Nicolás Medrano, Jorge Maurino, Tamara Castillo-Triviño
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Abstract

Disability accrual is mainly driven by progression independent of relapse activity, which is present even in early stages of relapsing-remitting multiple sclerosis (RRMS) and sometimes overlooked. This multicenter, non-interventional study evaluated whether patient-reported outcomes measures (PROMs) could capture disability in 189 early-stage RRMS patients (mean age: 36.1 ± 9.4 years, 71.4% female, mean disease duration: 1.4 ± 0.8 years, median EDSS: 1.0). The 9-Hole Peg Test (9-HPT), NeuroQoL Upper Extremity (NeuroQoL-UE), Timed 25-Foot Walk (T25-FW), Multiple Sclerosis Walking Scale (MSWS-12), Symbol Digit Modalities Test (SDMT), and Perceived Deficits Questionnaire (PDQ-5) were used to assess hand function, gait, and cognition, respectively. These functions were at least mildly affected in this early-stage population, finding significant correlations between PROMs and clinical assessments. PROMs could enable early-stage RRMS patients to communicate their perceived disability in different domains, assisting clinicians in disease monitoring and decision making.

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在早期复发缓解型多发性硬化症中使用自我报告和临床评估来检测残疾:寻找一种补充方法。
残疾的增加主要是由独立于复发活动的进展驱动的,即使在复发缓解型多发性硬化症(RRMS)的早期阶段也存在,有时被忽视。这项多中心、非介入性研究评估了189例早期RRMS患者(平均年龄:36.1±9.4岁,71.4%为女性,平均病程:1.4±0.8年,中位EDSS: 1.0)的患者报告结局测量(PROMs)是否可以捕获残疾。采用9孔Peg测试(9-HPT)、NeuroQoL上肢(NeuroQoL- ue)、25英尺步行时间(T25-FW)、多发性硬化症步行量表(MSWS-12)、符号数字形态测试(SDMT)和感知缺陷问卷(PDQ-5)分别评估了手功能、步态和认知。在这些早期人群中,这些功能至少受到轻微影响,发现PROMs与临床评估之间存在显著相关性。PROMs可以使早期RRMS患者在不同领域交流他们感知到的残疾,帮助临床医生进行疾病监测和决策。
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来源期刊
CiteScore
4.70
自引率
0.00%
发文量
54
审稿时长
15 weeks
期刊最新文献
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