Update on histone deacetylase inhibitors in peripheral T-cell lymphoma (PTCL).

IF 5.7 2区 医学 Q1 Medicine Clinical Epigenetics Pub Date : 2023-08-02 DOI:10.1186/s13148-023-01531-8
Guang Lu, Shikai Jin, Suwen Lin, Yuping Gong, Liwen Zhang, Jingwen Yang, Weiwei Mou, Jun Du
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Abstract

Peripheral T-cell lymphomas (PTCLs) are a group of highly aggressive malignancies with generally poor prognoses, and the first-line chemotherapy of PTCL has limited efficacy. Currently, several novel targeted agents, including histone deacetylase inhibitors (HDACis), have been investigated to improve the therapeutic outcome of PTCLs. Several HDACis, such as romidepsin, belinostat, and chidamide, have demonstrated favorable clinical efficacy and safety in PTCLs. More novel HDACis and new combination therapies are undergoing preclinical or clinical trials. Mutation analysis based on next-generation sequencing may advance our understanding of the correlation between epigenetic mutation profiles and relevant targeted therapies. Multitargeted HDACis and HDACi-based prodrugs hold promising futures and offer further directions for drug design.

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外周t细胞淋巴瘤(PTCL)组蛋白去乙酰化酶抑制剂的最新进展。
外周t细胞淋巴瘤(PTCL)是一组高度侵袭性的恶性肿瘤,通常预后较差,PTCL的一线化疗疗效有限。目前,一些新的靶向药物,包括组蛋白去乙酰化酶抑制剂(HDACis),已经被研究用于改善ptcl的治疗效果。几种HDACis,如罗米地辛、贝利诺他和奇达胺,在ptcl中显示出良好的临床疗效和安全性。更多的新型hdac和新的联合疗法正在进行临床前或临床试验。基于下一代测序的突变分析可以促进我们对表观遗传突变谱与相关靶向治疗之间关系的理解。多靶点HDACis和基于hdaci的前药前景广阔,为药物设计提供了进一步的方向。
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来源期刊
Clinical Epigenetics
Clinical Epigenetics Biochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
8.90
自引率
5.30%
发文量
150
审稿时长
12 weeks
期刊介绍: Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms in relation to human disease, diagnosis and therapy. Clinical trials and research in disease model organisms are particularly welcome.
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