KPT330 promotes the sensitivity of glioblastoma to olaparib by retaining SQSTM1 in the nucleus and disrupting lysosomal function.

IF 14.6 1区生物学 Q1 CELL BIOLOGY Autophagy Pub Date : 2024-02-01 Epub Date: 2023-09-15 DOI:10.1080/15548627.2023.2252301

Li-Hong Wang, Sen Wei, Ye Yuan, Ming-Jun Zhong, Jiao Wang, Ze-Xuan Yan, Kai Zhou, Tao Luo, Li Liang, Xiu-Wu Bian

引用次数: 0

Abstract

Abbreviations: AO: acridine orange; ATM: ATM serine/threonine kinase; CHEK1: checkpoint kinase 1; CHEK2: checkpoint kinase 2; CI: combination index; DMSO: dimethyl sulfoxide; DSBs: double-strand breaks; GBM: glioblastoma; HR: homologous recombination; H2AX: H2A.X variant histone; IHC: immunohistochemistry; LAPTM4B: lysosomal protein transmembrane 4 beta; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; PARP: poly(ADP-ribose) polymerase; RAD51: RAD51 recombinase; SQSTM1: sequestosome 1; SSBs: single-strand breaks; RNF168: ring finger protein 168; XPO1: exportin 1.

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KPT330通过将SQSTM1保留在细胞核中并破坏溶酶体功能，促进胶质母细胞瘤对奥拉帕尼的敏感性。

缩写：AO：吖啶橙；ATM:ATM丝氨酸/苏氨酸激酶；CHEK1：检查点激酶1；CHEK2：检查点激酶2；CI：组合指数；DMSO：二甲基亚砜；DSBs：双股断裂；GBM：胶质母细胞瘤；HR：同源重组；H2AX:H2A.X变体组蛋白；IHC：免疫组织化学；LAPTM4B：溶酶体蛋白跨膜4β；MAP1LC3/LC3：微管相关蛋白1轻链3；PARP：聚ADP核糖聚合酶；RAD51:RAD51重组酶；SQSTM1：螯合体1；SSBs：单链断裂；RNF168：环指蛋白168；XPO1:在1中导出。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autophagy 生物-细胞生物学

CiteScore

21.30

自引率

2.30%

发文量

277

审稿时长

1 months

期刊介绍： Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.