Roles and Effects of Interferon Lambda Signaling in the Context of Bacterial Infections.

IF 1.9 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Journal of Interferon and Cytokine Research Pub Date : 2023-09-01 Epub Date: 2023-06-08 DOI:10.1089/jir.2023.0037
Da'Kuawn Johnson, Nicholas Carbonetti
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Abstract

Type III interferon, or interferon lambda (IFNλ), was discovered 20 years ago and has been studied primarily for its role in combatting viral infections. However, it is also induced in response to certain bacterial infections but its roles and effects in this context are relatively poorly understood. In this mini review, we discuss the roles of IFNλ signaling in bacterial infections, highlighting its deleterious or protective effects for different infections. We also discuss a couple of recent studies showing that some bacteria possess defense mechanisms against the effects of IFNλ. We hope that this review will spur further investigation into the roles of IFNλ in the context of bacterial infections and will promote considerations of its therapeutic potential for these infections.

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干扰素Lambda信号传导在细菌感染中的作用和影响。
III型干扰素,或称干扰素λ,20年前被发现,主要因其在对抗病毒感染中的作用而被研究。然而,它也会在对某些细菌感染的反应中被诱导,但它在这种情况下的作用和影响相对来说知之甚少。在这篇小型综述中,我们讨论了IFNλ信号在细菌感染中的作用,强调了其对不同感染的有害或保护作用。我们还讨论了最近的几项研究,这些研究表明一些细菌对IFNλ的作用具有防御机制。我们希望这篇综述将推动对IFNλ在细菌感染中的作用的进一步研究,并促进对其治疗这些感染潜力的考虑。
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来源期刊
CiteScore
3.80
自引率
0.00%
发文量
78
审稿时长
2.2 months
期刊介绍: Journal of Interferon & Cytokine Research (JICR) provides the latest groundbreaking research on all aspects of IFNs and cytokines. The Journal delivers current findings on emerging topics in this niche community, including the role of IFNs in the therapy of diseases such as multiple sclerosis, the understanding of the third class of IFNs, and the identification and function of IFN-inducible genes.
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