Activated STING1 rides the Rafeesome.

IF 14.6 1区 生物学 Q1 CELL BIOLOGY Autophagy Pub Date : 2023-12-01 Epub Date: 2023-08-06 DOI:10.1080/15548627.2023.2240154
Yaping Han, Jianfei Zheng, Liang Ge
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Abstract

Over the past decade, accumulated studies have reported the presence of non-canonical macroautophagy/autophagy characterized by the shared usage of the autophagy machinery and distinct components that function in multiple scenarios but do not involve lysosomal degradation. One type of non-canonical autophagy is secretory autophagy, which facilitates the secretion of various cargoes. In a recent work from Gao et al. the ER-membrane protein STING1 has been identified as a novel substrate of secretory autophagy. The secretion of activated STING1 is mediated by its packing into the rafeesome, a newly identified organelle formed upon the fusion of RAB22A-mediated non-canonical autophagosome with an early endosome. Moreover, extracellular vesicles containing activated STING1 induce antitumor immunity in recipient cells, a process potentially promoted by RAB22A.

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激活的STING1乘坐Rafeesome。
在过去的十年里,积累的研究报告了非典型的大自噬/自噬的存在,其特征是共同使用自噬机制和在多种情况下发挥作用但不涉及溶酶体降解的不同成分。一种非典型的自噬是分泌性自噬,它促进各种货物的分泌。在Gao等人最近的一项工作中,ER膜蛋白STING1已被鉴定为分泌性自噬的新底物。活化的STING1的分泌是通过其堆积到rafeesome中来介导的,Rafeesomes是一种新鉴定的细胞器,由RAB22A介导的非典型自噬体与早期内体融合而形成。此外,含有活化STING1的细胞外小泡在受体细胞中诱导抗肿瘤免疫,这一过程可能由RAB22A促进。
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来源期刊
Autophagy
Autophagy 生物-细胞生物学
CiteScore
21.30
自引率
2.30%
发文量
277
审稿时长
1 months
期刊介绍: Autophagy is a peer-reviewed journal that publishes research on autophagic processes, including the lysosome/vacuole dependent degradation of intracellular material. It aims to be the premier journal in the field and covers various connections between autophagy and human health and disease, such as cancer, neurodegeneration, aging, diabetes, myopathies, and heart disease. Autophagy is interested in all experimental systems, from yeast to human. Suggestions for specialized topics are welcome. The journal accepts the following types of articles: Original research, Reviews, Technical papers, Brief Reports, Addenda, Letters to the Editor, Commentaries and Views, and Articles on science and art. Autophagy is abstracted/indexed in Adis International Ltd (Reactions Weekly), EBSCOhost (Biological Abstracts), Elsevier BV (EMBASE and Scopus), PubMed, Biological Abstracts, Science Citation Index Expanded, Web of Science, and MEDLINE.
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