Dietary zinc intake in relation to migraine among adults: a cross sectional study of NHANES 1999-2004.

IF 3.6 4区医学 Q2 NEUROSCIENCES Nutritional Neuroscience Pub Date : 2024-06-01 Epub Date: 2023-08-04 DOI:10.1080/1028415X.2023.2243678

Heqing Zheng, Sheng Tian, Lanxiang Wu, Xianhui Zhong, Mingxu Liu, Xinping Yu, Yonggang Xie, Wei Wu

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Abstract

Background: Previous studies have revealed that an antioxidant diet is a protective factor against migraine. However, the association between zinc, an important antioxidant obtained from the diet, and migraine has received little attention. The purpose of this study was to explore the association between zinc intake with migraine.

Methods: The present study used cross-sectional data from individuals who participated in the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2004. Logistic regression models and restricted cubic spline models were performed to explore the association between zinc intake and migraine.

Results: A total of 9849 adults aged 20 years or older were included in this study. Zinc intake was negatively associated with migraine. Compared to participants in the lowest group of dietary zinc intake Q1 (≤5.93 mg/day), the adjusted ORs for migraine in Q2 (5.94-8.38 mg/day), Q3 (8.39-11.26 mg/day), Q4 (11.27-15.75 mg/day), and Q5 (≥15.76 mg/day) were 0.73 (95% CI: 0.60-0.89, p = 0.004), 0.72 (95% CI: 0.55-0.95, p = 0.02), 0.76 (95% CI: 0.58-0.99, p = 0.04) and 0.73 (95% CI: 0.50-1.05, p = 0.08), respectively. Our findings also suggested an interaction between zinc intake and age (P for interaction = 0.007). Additionally, the relationship between zinc intake and migraine in adults with 20-50 years was non-linear.

Conclusions: A higher zinc intake is significantly associated with a decreased prevalence of migraine, and age can modify the association between them.

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膳食锌摄入量与成人偏头痛的关系：1999-2004 年 NHANES 横断面研究。

背景：以往的研究表明，抗氧化饮食是偏头痛的一个保护因素。然而，从饮食中获取的重要抗氧化剂锌与偏头痛之间的关系却很少受到关注。本研究旨在探讨锌摄入量与偏头痛之间的关系：本研究使用了 1999 年至 2004 年间参加美国国家健康与营养调查（NHANES）的横断面数据。采用逻辑回归模型和限制性立方样条模型来探讨锌摄入量与偏头痛之间的关系：这项研究共纳入了 9849 名 20 岁或以上的成年人。锌摄入量与偏头痛呈负相关。与膳食锌摄入量最低组 Q1（≤5.93 毫克/天）的参与者相比，Q2（5.94-8.38 毫克/天）、Q3（8.39-11.26 毫克/天）、Q4（11.27-15.75 毫克/天）和 Q5（≥15.76毫克/天）分别为0.73（95% CI：0.60-0.89，p = 0.004）、0.72（95% CI：0.55-0.95，p = 0.02）、0.76（95% CI：0.58-0.99，p = 0.04）和0.73（95% CI：0.50-1.05，p = 0.08）。我们的研究结果还表明，锌摄入量与年龄之间存在交互作用（交互作用的 P = 0.007）。此外，在 20-50 岁的成年人中，锌摄入量与偏头痛之间的关系是非线性的：结论：锌摄入量越高，偏头痛发病率越低，而年龄会改变两者之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nutritional Neuroscience 医学-神经科学

CiteScore

8.50

自引率

2.80%

发文量

236

审稿时长

>12 weeks

期刊介绍： Nutritional Neuroscience is an international, interdisciplinary broad-based, online journal for reporting both basic and clinical research in the field of nutrition that relates to the central and peripheral nervous system. Studies may include the role of different components of normal diet (protein, carbohydrate, fat, moderate use of alcohol, etc.), dietary supplements (minerals, vitamins, hormones, herbs, etc.), and food additives (artificial flavours, colours, sweeteners, etc.) on neurochemistry, neurobiology, and behavioural biology of all vertebrate and invertebrate organisms. Ideally this journal will serve as a forum for neuroscientists, nutritionists, neurologists, psychiatrists, and those interested in preventive medicine.