Maternal and fetal outcomes in pregnant patients with non-cirrhotic portal hypertension: A systematic review and meta-analysis.

IF 0.8 Q4 OBSTETRICS & GYNECOLOGY Obstetric Medicine Pub Date : 2023-09-01 Epub Date: 2023-01-17 DOI:10.1177/1753495X221143864

Suprabhat Giri, Shradhanjali Sahoo, Sridhar Sundaram, Akash Shukla

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Abstract

Background: Concerned studies with respect to the outcome of pregnant patients with non-cirrhotic portal hypertension are limited. Thus, a systematic review and meta-analysis of the available literature was conducted.

Methods: A literature search was conducted from 1999 to December 2021 for studies evaluating pregnancy outcomes in patients with non-cirrhotic portal hypertension.

Results: Twelve studies were included in the meta-analysis. The pooled rate of variceal bleeding, ascites and severe anemia requiring blood transfusion were 9.6%, 2.3%, and 14.9%, respectively. The pooled rate of spontaneous miscarriage, gestational hypertension, delivery by cesarean section, and postpartum hemorrhage were 11.9%, 4.5%, 36.7%, and 4.7%, respectively. The pooled stillbirth rate was 2.5% and among the live births, the pooled rates of preterm birth, low birth weight, intensive care unit admission, and neonatal mortality were 21.6%, 18.7%, 15.5%, and 1.8%, respectively.

Conclusion: Pregnancy in patients with non-cirrhotic portal hypertension is associated with increased maternal & fetal morbidity but mortality remains low.

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非肝硬化门静脉高压症孕妇的母体和胎儿结局：系统回顾和荟萃分析。

背景：有关非肝硬化门静脉高压症妊娠患者预后的研究十分有限。因此，我们对现有文献进行了系统回顾和荟萃分析：方法：对 1999 年至 2021 年 12 月期间评估非肝硬化门脉高压症患者妊娠结局的研究进行了文献检索：荟萃分析纳入了 12 项研究。需要输血的静脉曲张出血、腹水和严重贫血的总发生率分别为 9.6%、2.3% 和 14.9%。自然流产、妊娠高血压、剖宫产和产后出血的汇总率分别为 11.9%、4.5%、36.7% 和 4.7%。总死胎率为 2.5%，在活产婴儿中，早产、低出生体重、入住重症监护室和新生儿死亡率分别为 21.6%、18.7%、15.5% 和 1.8%：结论：非肝硬化性门脉高压症患者妊娠会增加母体和胎儿的发病率，但死亡率仍然很低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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