Transcriptome Data Reveal Geographic Heterogeneity in Gene Expression in Patients with Prostate Cancer.

IF 1.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Reports of Biochemistry and Molecular Biology Pub Date : 2023-04-01 DOI:10.52547/rbmb.12.1.92
Yi Zheng, Yang Wang, Haitian He, Zhuping Zou, Huiling Lu, Jinlong Li, Jun Cai, Kebing Wang
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Abstract

Background: The incidence of prostate cancer (PC) exhibits geographical heterogeneity. However, the metabolic mechanisms underlying this geographic heterogeneity remain unclear. This study aimed to reveal the metabolic mechanism of the geographic heterogeneity in the incidence of PC.This study aimed to investigate the anti-cancer effects of different gum extracts on metabolic changes and their impact on gene expression in HT-29 cell.

Methods: Transcriptomic data from public databases were obtained and analyzed to screen geographic-differentially expressed genes and metabolic pathways. Associations between these differentially expressed genes and the incidence of PC were determined to identify genes that were highly associated with PC incidence. A co-expression network analysis was performed to identify geographic-specific regulatory pathways.

Results: A total of 175 differentially expressed genes were identified in four countries and were associated with the regulation of DNA replication and the metabolism of pyrimidine, nucleotides, purines, and galactose.Additionally, the expression of the genes CLVS2, SCGB1A1, KCNK3, HHIPL2, MMP26, KCNJ15, and PNMT was highly correlated with the incidence of PC. Geographic-specific differentially expressed genes in low-incidence areas were highly correlated with KCNJ15, MMP26, KCNK3, and SCCB1A1, which play a major role in ion channel-related functions.

Conclusions: This study suggests that geographic heterogeneity in PC incidence is associated with the expression levels of genes associated with amino acid metabolism, lipid metabolism, and ion channels.

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转录组数据揭示癌症前列腺患者基因表达的地理异质性。
背景:癌症(PC)的发病率具有地理异质性。然而,这种地理异质性背后的代谢机制尚不清楚。本研究旨在揭示PC发病地理异质性的代谢机制。本研究旨在研究不同树胶提取物对HT-29细胞代谢变化的抗癌作用及其对基因表达的影响。方法:从公共数据库中获得转录组数据并进行分析,以筛选地理差异表达基因和代谢途径。确定这些差异表达基因与PC发病率之间的相关性,以确定与PC发病高度相关的基因。进行共表达网络分析以确定地理特异性调控途径。结果:在四个国家共鉴定出175个差异表达基因,这些基因与DNA复制和嘧啶、核苷酸、嘌呤和半乳糖代谢的调节有关。此外,基因CLVS2、SCGB1A1、KCNK3、HHIPL2、MMP26、KCNJ15和PNMT的表达与PC的发病率高度相关。低发病地区的地理特异性差异表达基因与KCNJ115、MMP26,KCNK3和SCCB1A1高度相关,这些基因在离子通道相关功能中起主要作用。结论:本研究表明,PC发病率的地理异质性与氨基酸代谢、脂质代谢和离子通道相关基因的表达水平有关。
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来源期刊
Reports of Biochemistry and Molecular Biology
Reports of Biochemistry and Molecular Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
2.80
自引率
23.50%
发文量
60
审稿时长
10 weeks
期刊介绍: The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.
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