The Potential of Berberine to Target Telocytes in Rabbit Heart.

IF 2.1 4区医学 Q3 CHEMISTRY, MEDICINAL Planta medica Pub Date : 2024-02-01 Epub Date: 2023-09-15 DOI:10.1055/a-2176-5881

Min Yang, Tong Yang, Lu Mei, Yingxing Zhang, Chunhua Liang, Xuebing Bai, Zhenwei Zhang, Yonghong Shi, Qiusheng Chen

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Abstract

A brand-new class of interstitial cells, called telocytes, has been detected in the heart. Telocytes can connect and transmit signals to almost all cardiomyocytes; this is highly interrelated with the occurrence and development of heart diseases. Modern studies have shown that berberine has a therapeutic effect on cardiovascular health. However, berberine's mechanism of action on the cardiovascular system through cardiac telocytes is unclear. Interestingly, 5 µm of berberine remarkably decreased the concentration of intracellular calcium and membrane depolarization in cultured telocytes, upregulated the expression of CX43 and β-catenin, and downregulated the expressions of TRPV4 and TRPV1. Here, telocytes were identified in the vascular adventitia and intima, endocardium, myocardium, adventitia, and heart valves. Moreover, telocytes were broadly dispersed around cardiac vessels and interacted directly through gap junctions and indirectly through extracellular vesicles. Together, cardiac telocytes interact with berberine and then deliver drug information to the heart. Telocytes may be an essential cellular target for drug therapy of the cardiovascular system.

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黄连素靶向兔心脏Tel细胞的潜力。

在心脏中检测到一种全新的间质细胞，称为毛细血管细胞。Telocytes可以连接并向几乎所有的心肌细胞传递信号；这与心脏病的发生和发展密切相关。现代研究表明，黄连素对心血管健康有治疗作用。然而，黄连素通过心脏毛细血管细胞对心血管系统的作用机制尚不清楚。有趣的是，5 µm的黄连素显著降低培养的毛细血管细胞的细胞内钙浓度和膜去极化，上调CX43和β-catenin的表达，下调TRPV4和TRPV1的表达。在这里，在血管外膜和内膜、心内膜、心肌、外膜和心脏瓣膜中发现了毛细血管细胞。此外，毛细血管细胞广泛分布在血管周围，并通过间隙连接直接相互作用，间接通过细胞外小泡相互作用。心脏毛细血管细胞与黄连素相互作用，然后将药物信息传递到心脏。Telocytes可能是心血管系统药物治疗的重要细胞靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Planta medica 医学-药学

CiteScore

5.10

自引率

3.70%

发文量

101

审稿时长

1.8 months

期刊介绍： Planta Medica is one of the leading international journals in the field of natural products – including marine organisms, fungi as well as micro-organisms – and medicinal plants. Planta Medica accepts original research papers, reviews, minireviews and perspectives from researchers worldwide. The journal publishes 18 issues per year. The following areas of medicinal plants and natural product research are covered: -Biological and Pharmacological Activities -Natural Product Chemistry & Analytical Studies -Pharmacokinetic Investigations -Formulation and Delivery Systems of Natural Products. The journal explicitly encourages the submission of chemically characterized extracts.