No gender differences in the pharmacological emergency treatment of schizophrenia: results of a 21-year observation.

IF 2.1 3区 医学 Q3 PHARMACOLOGY & PHARMACY International Clinical Psychopharmacology Pub Date : 2024-01-01 Epub Date: 2023-08-09 DOI:10.1097/YIC.0000000000000495
Monika Edlinger, Stefanie Brettbacher, Timo Schurr, Nursen Yalcin-Siedentopf, Alex Hofer
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引用次数: 1

Abstract

Patients suffering from schizophrenia are at high risk for admission and treatment in locked units. This study investigated gender differences in the pharmacological emergency treatment of schizophrenia patients over a 21-year observation period. The current retrospective study was conducted at the Division of Psychiatry I of the Medical University Innsbruck. All adult patients (n = 845; 425 female) suffering from schizophrenia who were admitted involuntarily to one of the acute psychiatric units in the years 1997, 2002, 2007, 2012 and 2017 were included in the study. In the years mentioned above, 590 schizophrenia patients (297 men, 293 women) admitted to a locked unit received pharmacological emergency treatment. With the exception of clozapine which was more frequently administered to men no significant differences between men and women were found in terms of the choice, dosage, and type of application of medication (antipsychotics and benzodiazepines). Since most treatment guidelines for schizophrenia do not consider gender differences at all, it is not surprising that acute treatment is almost the same for men and women. However, in times when individualized therapies gain more and more importance, the consideration of sex differences should be part of new treatment concepts.

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精神分裂症的药物急救治疗无性别差异:一项21年观察的结果
精神分裂症患者在闭锁病房住院和治疗的风险很高。本研究通过21年的观察,探讨了精神分裂症患者紧急药物治疗的性别差异。目前的回顾性研究是在因斯布鲁克医科大学精神病学一科进行的。所有成年患者(n = 845;研究纳入了1997年、2002年、2007年、2012年和2017年非自愿入住急性精神科的425名女性精神分裂症患者。在上述年份,有590名精神分裂症患者(297名男性,293名女性)入住一个封闭的病房,接受了药物紧急治疗。除了氯氮平更常用于男性之外,在药物的选择、剂量和应用类型(抗精神病药和苯二氮卓类药物)方面,男性和女性之间没有发现显著差异。由于大多数精神分裂症的治疗指南根本不考虑性别差异,因此男性和女性的急性治疗几乎相同也就不足为奇了。然而,在个体化治疗越来越重要的时代,考虑性别差异应该成为新的治疗理念的一部分。
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来源期刊
CiteScore
4.40
自引率
23.10%
发文量
97
审稿时长
>12 weeks
期刊介绍: International Clinical Psychopharmacology provides an essential link between research and clinical practice throughout psychopharmacology. It reports on studies in human subjects, both healthy volunteers and patients, which relate the effects of drugs on psychological processes. A major objective of the journal is to publish fully refereed papers which throw light on the ways in which the study of psychotropic drugs can increase our understanding of psychopharmacology. To this end the journal publishes results of early Phase I and II studies, as well as those of controlled clinical trials of psychotropic drugs in Phase II and IV. Other topics covered include the epidemiology of psychotropic drug prescribing and drug taking, the sociology of psychotropic drugs including compliance, and research into the safety and adverse effects of these compounds.
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