Plasma Lipoprotein(a) Levels in Polycystic Ovary Syndrome: A Systematic Review and Meta-analysis.

IF 3.1 Q2 PERIPHERAL VASCULAR DISEASE High Blood Pressure & Cardiovascular Prevention Pub Date : 2023-07-01 DOI:10.1007/s40292-023-00585-2

Walter Masson, Leandro Barbagelata, Martín Lobo, Augusto Lavalle-Cobo, Pablo Corral, Juan Patricio Nogueira

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Abstract

Introduction: The polycystic ovary syndrome (PCOS) may represent an important model of lipid alterations. Lipoprotein(a) [Lp(a)] has emerged as a new marker of cardiovascular risk.

Aim: The main objective of this meta-analysis was to analyze the available evidence on Lp(a) levels in patients with PCOS compared to a control group.

Methods: This meta-analysis was performed according to PRISMA guidelines. A literature search was performed to detect studies that have quantified Lp(a) levels in women with PCOS compared to a control group. The primary outcome was Lp(a) levels expressed in mg/dL. Random effects models were used.

Results: Twenty-three observational studies including 2,337 patients were identified and considered eligible for this meta-analysis. In the overall analysis, the quantitative analysis showed that patients with PCOS have a higher Lp(a) levels (SMD: 1.1 [95% CI: 0.7 to 1.4]; I²=93%) compared to the control group. The results were similar in the analysis of the subgroups of patients according to body mass index (normal weight group: SMD: 1.2 [95% CI: 0.5 to 1.9], I²=95%; overweight group: SMD: 1.2 [95% CI: 0.5 to 1.8], I²=89%). Sensitivity analysis showed that the results were robust.

Conclusions: This meta-analysis shows that women with PCOS had higher levels of Lp(a) compared to healthy women used as a control group. These findings were observed in both overweight and non-overweight women.

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血浆脂蛋白(a)水平在多囊卵巢综合征:一个系统回顾和荟萃分析。

简介:多囊卵巢综合征(PCOS)可能是脂质改变的一个重要模型。脂蛋白(a) [Lp(a)]已成为心血管风险的新标志。目的:本荟萃分析的主要目的是分析PCOS患者与对照组相比Lp(a)水平的现有证据。方法:根据PRISMA指南进行meta分析。进行文献检索，以检测与对照组相比，PCOS妇女Lp(A)水平量化的研究。主要终点是以mg/dL表示的Lp(a)水平。采用随机效应模型。结果:23项观察性研究，包括2337例患者，被认为符合本荟萃分析。在总体分析中，定量分析显示PCOS患者的Lp(a)水平较高(SMD: 1.1 [95% CI: 0.7 ~ 1.4];I2=93%)与对照组相比。根据体重指数对患者进行亚组分析的结果相似(正常体重组:SMD: 1.2 [95% CI: 0.5 ~ 1.9]， I2=95%;超重组:SMD: 1.2 [95% CI: 0.5 ~ 1.8]， I2=89%)。敏感性分析表明，结果是稳健的。结论:该荟萃分析显示，与对照组的健康女性相比，PCOS女性的Lp(a)水平较高。这些发现在超重和非超重的女性中都有观察到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

High Blood Pressure & Cardiovascular Prevention PERIPHERAL VASCULAR DISEASE-

CiteScore

5.70

自引率

3.30%

发文量

期刊介绍： High Blood Pressure & Cardiovascular Prevention promotes knowledge, update and discussion in the field of hypertension and cardiovascular disease prevention, by providing a regular programme of independent review articles covering key aspects of the management of hypertension and cardiovascular diseases. The journal includes: Invited ''State of the Art'' reviews. Expert commentaries on guidelines, major trials, technical advances.Presentation of new intervention trials design.''Pros and Cons'' or round tables on controversial issues.Statements on guidelines from hypertension and cardiovascular scientific societies.Socio-economic issues.Cost/benefit in prevention of cardiovascular diseases.Monitoring of healthcare systems.News and views from the Italian Society of Hypertension (including abstracts).All manuscripts are subject to peer review by international experts. Letters to the editor are welcomed and will be considered for publication.