Targeting N-cadherin (CDH2) and the malignant bone marrow microenvironment in acute leukaemia.

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2023-05-03 DOI:10.1017/erm.2023.13
Jessica Parker, Sean Hockney, Orest W Blaschuk, Deepali Pal
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引用次数: 3

Abstract

This review discusses current research on acute paediatric leukaemia, the leukaemic bone marrow (BM) microenvironment and recently discovered therapeutic opportunities to target leukaemia-niche interactions. The tumour microenvironment plays an integral role in conferring treatment resistance to leukaemia cells, this poses as a key clinical challenge that hinders management of this disease. Here we focus on the role of the cell adhesion molecule N-cadherin (CDH2) within the malignant BM microenvironment and associated signalling pathways that may bear promise as therapeutic targets. Additionally, we discuss microenvironment-driven treatment resistance and relapse, and elaborate the role of CDH2-mediated cancer cell protection from chemotherapy. Finally, we review emerging therapeutic approaches that directly target CDH2-mediated adhesive interactions between the BM cells and leukaemia cells.

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靶向n -钙粘蛋白(CDH2)与急性白血病恶性骨髓微环境的关系。
本文综述了急性儿科白血病的研究现状、白血病骨髓(BM)微环境以及最近发现的靶向白血病-生态位相互作用的治疗机会。肿瘤微环境在赋予白血病细胞治疗耐药性方面起着不可或缺的作用,这是阻碍这种疾病管理的关键临床挑战。在这里,我们关注细胞粘附分子n -钙粘蛋白(CDH2)在恶性脑转移微环境中的作用以及可能作为治疗靶点的相关信号通路。此外,我们讨论了微环境驱动的治疗耐药和复发,并阐述了cdh2介导的癌细胞对化疗的保护作用。最后,我们回顾了直接针对骨髓细胞和白血病细胞之间cdh2介导的粘附相互作用的新兴治疗方法。
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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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