Relationship between Uric Acid to High Density Lipoprotein Cholesterol Ratio and Nonalcoholic Fatty Liver Disease in Nonoverweight/Obese Patients with Type 2 Diabetes.
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Abstract
Aims: To investigate the relationship between uric acid to high-density lipoprotein cholesterol ratio (UHR) levels and nonalcoholic fatty liver disease (NAFLD) in nonoverweight/obese patients with type 2 diabetes.
Methods: A retrospective study was designed including a total of 343 inpatients with type 2 diabetes whose BMI<24 kg/m2. The population was divided into three groups as the UHR tertiles. Logistic regression analysis was performed to estimate odds ratios (ORs) of UHR for NAFLD. ROC curve analysis was used to estimate the diagnostic value of UHR for NAFLD.
Results: The prevalence rat of NAFLD enhanced progressively from the tertile 1 to tertile 3 of UHR (30.70% vs. 56.52% vs. 73.68%). Logistic regression analysis showed that participants in the higher UHR groups, compared with those in the first tertile group, had higher occurrence risks for NAFLD. The positive association between UHR and NAFLD was independent of age, BMI, blood pressure, hepatic enzymes, and other components of metabolic disorders. ROC curve analysis showed that the area under curve (AUC), sensitivity, and specificity for UHR were 0.697, 0.761, and 0.553, respectively.
Conclusions: In type 2 diabetic patients without overweight or obesity, UHR is significantly associated with NAFLD and can be used as a novel and useful predictor for NAFLD onset.
目的:探讨非超重/肥胖2型糖尿病患者尿酸与高密度脂蛋白胆固醇比值(UHR)水平与非酒精性脂肪性肝病(NAFLD)的关系。方法:对343例BMI2的住院2型糖尿病患者进行回顾性研究。人口被分为三组，称为UHR四组。采用Logistic回归分析估计NAFLD患者UHR的优势比(ORs)。采用ROC曲线分析估计UHR对NAFLD的诊断价值。结果:从UHR 1分位到3分位NAFLD患病率逐渐增高(30.70% vs. 56.52% vs. 73.68%)。Logistic回归分析显示，与第一组相比，高UHR组的参与者NAFLD的发生风险更高。UHR和NAFLD之间的正相关与年龄、BMI、血压、肝酶和其他代谢紊乱成分无关。ROC曲线分析显示，UHR的曲线下面积(AUC)、敏感性和特异性分别为0.697、0.761和0.553。结论:在没有超重或肥胖的2型糖尿病患者中，UHR与NAFLD显著相关，可以作为NAFLD发病的一种新的有用的预测指标。
期刊介绍：
International Journal of Endocrinology is a peer-reviewed, Open Access journal that provides a forum for scientists and clinicians working in basic and translational research. The journal publishes original research articles, review articles, and clinical studies that provide insights into the endocrine system and its associated diseases at a genomic, molecular, biochemical and cellular level.
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