Capillary blood sampling for the determination of clozapine concentrations: analytical validation and patient experience.

IF 2.1 3区医学 Q3 PHARMACOLOGY & PHARMACY International Clinical Psychopharmacology Pub Date : 2024-01-01 Epub Date: 2023-08-07 DOI:10.1097/YIC.0000000000000494

Bianca D Breken, Koen P Grootens, Annemieke M Vermeulen Windsant-van den Tweel, Walter A Hermens, Hieronymus J Derijks

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引用次数: 2

Abstract

Patients may be reluctant to start clozapine (CLZ) because of the frequent blood sampling needed for white blood cell monitoring, but also therapeutic drug monitoring of CLZ. Finger prick, instead of venepuncture, might lower the threshold to CLZ use. The aim of this study was to determine whether CLZ concentrations are the same in capillary and venous blood samples. Capillary blood was drawn by finger prick and collected in the Hem-Col tube. Paired capillary and venous blood samples were collected from inpatients and outpatients of a mental health institute. Patients were asked to rate pain, experience, and preference for blood sampling method. Passing-Bablok analysis of 40 paired samples showed that CLZ concentrations were statistically equal in capillary and venous samples {slope 0.96 [95% confidence interval (CI): 0.88-1.04], intercept -6.86 (95% CI: -30.75 to 24.13)}. Venepuncture was the preferred method based on the experience ( P = 0.009) and preference ( P = 0.043) items. In conclusion, CLZ concentrations were similar in venous and capillary blood samples. Venepuncture appeared to be preferred to finger prick for blood sampling. Our results emphasize the importance of consulting patients' individual preference for blood sampling method.

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毛细管血液取样测定氯氮平浓度:分析验证和患者经验。

患者可能不愿意开始使用氯氮平(CLZ)，因为需要频繁采血进行白细胞监测，同时也需要对CLZ进行治疗药物监测。手指刺破，而不是静脉穿刺，可能会降低使用CLZ的门槛。本研究的目的是确定CLZ浓度在毛细血管和静脉血样品中是否相同。采用手指穿刺法抽取毛细血管血，Hem-Col管采集。从精神卫生机构的住院患者和门诊患者中采集配对的毛细血管和静脉血样本。患者被要求对疼痛、经验和对采血方法的偏好进行评分。40个配对样本的passin - bablok分析显示，在毛细血管和静脉样本中CLZ浓度在统计学上相等{斜率0.96[95%可信区间(CI): 0.88-1.04]，截距-6.86 (95% CI: -30.75 ~ 24.13)}。根据经验(P = 0.009)和偏好(P = 0.043)项，静脉穿刺是首选方法。结论:大鼠静脉血和毛细血管血CLZ浓度相近。静脉穿刺似乎比手指穿刺更适合采血。我们的研究结果强调了咨询患者对血液采样方法的个人偏好的重要性。

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来源期刊

International Clinical Psychopharmacology 医学-精神病学

CiteScore

4.40

自引率

23.10%

发文量

审稿时长

>12 weeks

期刊介绍： International Clinical Psychopharmacology provides an essential link between research and clinical practice throughout psychopharmacology. It reports on studies in human subjects, both healthy volunteers and patients, which relate the effects of drugs on psychological processes. A major objective of the journal is to publish fully refereed papers which throw light on the ways in which the study of psychotropic drugs can increase our understanding of psychopharmacology. To this end the journal publishes results of early Phase I and II studies, as well as those of controlled clinical trials of psychotropic drugs in Phase II and IV. Other topics covered include the epidemiology of psychotropic drug prescribing and drug taking, the sociology of psychotropic drugs including compliance, and research into the safety and adverse effects of these compounds.