The Prospective Lynch Syndrome Database: background, design, main results and complete MySQL code.

IF 2 4区 医学 Q3 ONCOLOGY Hereditary Cancer in Clinical Practice Pub Date : 2022-11-21 DOI:10.1186/s13053-022-00243-z
Pål Møller
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引用次数: 3

Abstract

A brief description of why and for which purposes the Prospective Lynch Syndrome Database was established, the principles and design, and the main classes of results are given. Data input is assumption-free input enabling validation of paradigms used to explain the results. The design is considering cancer/age as discrete events to occur or not in a time dimension in a closed room compliant with population genetic paradigms and last centuries developing paradigms of interpreting discrete events reflecting conditional and/or co-occurring stochastic probabilities. Which may be in contrast to the paradigm that any observed event has a cause. The results may indicate that some current paradigms on carcinogenesis should be reconsidered. The complete analytic code in MySQL© syntax together with a flowchart illustrating how the different pieces of codes interrelate are included as supplementary files, enabling third parties to use or modify the code to examine prospectively observed events in their own activities when referring to this report as the source.

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前瞻性Lynch综合征数据库:背景、设计、主要结果和完整的MySQL代码。
简要介绍了建立前瞻性Lynch综合征数据库的原因和目的,原则和设计,以及结果的主要类别。数据输入是无假设的输入,可以验证用于解释结果的范式。该设计将癌症/年龄视为离散事件,在一个封闭的房间里,在一个时间维度上发生或不发生,符合人口遗传范式和上个世纪发展的范式,这些范式解释了反映条件和/或共同发生的随机概率的离散事件。这可能与任何观察到的事件都有原因的范式相反。这一结果可能表明,目前的一些关于癌变的范式应该重新考虑。MySQL©语法中的完整分析代码与说明不同代码片段如何相互关联的流程图一起作为补充文件包含,使第三方能够使用或修改代码,以便在引用此报告作为源时检查自己活动中的前瞻性观察事件。
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来源期刊
CiteScore
3.10
自引率
5.90%
发文量
38
审稿时长
>12 weeks
期刊介绍: Hereditary Cancer in Clinical Practice is an open access journal that publishes articles of interest for the cancer genetics community and serves as a discussion forum for the development appropriate healthcare strategies. Cancer genetics encompasses a wide variety of disciplines and knowledge in the field is rapidly growing, especially as the amount of information linking genetic differences to inherited cancer predispositions continues expanding. With the increased knowledge of genetic variability and how this relates to cancer risk there is a growing demand not only to disseminate this information into clinical practice but also to enable competent debate concerning how such information is managed and what it implies for patient care. Topics covered by the journal include but are not limited to: Original research articles on any aspect of inherited predispositions to cancer. Reviews of inherited cancer predispositions. Application of molecular and cytogenetic analysis to clinical decision making. Clinical aspects of the management of hereditary cancers. Genetic counselling issues associated with cancer genetics. The role of registries in improving health care of patients with an inherited predisposition to cancer.
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