Analysis of related factors affecting hemoporfin-mediated photodynamic therapy for port-wine stain: A retrospective study.

IF 2.5 4区医学 Q2 DERMATOLOGY Photodermatology, photoimmunology & photomedicine Pub Date : 2023-09-01 DOI:10.1111/phpp.12874

Jiajie Chen, Yu Gui, Sun Wang, Dawei Huang, Jiajie Lyu, Hui Cheng, Yantao Ding, Huabing Zhang, Shengxiu Liu

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引用次数: 1

Abstract

Background: Hemoporfin-mediated photodynamic therapy (HMME-PDT) is currently considered one of the most promising therapies for port-wine stain (PWS). However, the efficacy of this is very variable and needs further studies.

Methods: A total of 101 patients with PWS in the face, neck, or extremities who received at least 2 HMME-PDT sessions were included in the study, and correlations of efficacy with age, gender, locations, treatment sessions, and PDL treatment history were analyzed.

Results: The efficacy of HMME-PDT in patients with different ages, locations, and different numbers of prior PDL treatment showed constantly significant differences after 1/2/last session (p < .05). The number of treatments was associated with efficacy, and patients who received more than two sessions had a better response than those who underwent two sessions only (p < .001). Ordinal logistic regression analysis confirmed the above-mentioned associations. Nevertheless, patients of different sex, subtype, and lesion size showed no significant differences.

Conclusions: Our studies demonstrated that HMME-PDT is effective in the treatment of PWS. The more prior PDL treatments, older age, lips involvement, PWS on limbs were adverse factors for Hemoporfin-PDT, while multiple HMME-PDT sessions can improve effective and response rate. Besides, ambient temperature and lesions temperature should be concerned, local cooling provides some relief from pain but may influence effect.

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影响血红蛋白介导的葡萄酒色斑光动力治疗的相关因素分析:一项回顾性研究。

背景:hemoporin介导的光动力疗法(HMME-PDT)被认为是目前最有前途的治疗port-wine stain (PWS)的方法之一。然而，这种方法的效果变化很大，需要进一步研究。方法:本研究共纳入101例面部、颈部或四肢PWS患者，患者接受了至少2次HMME-PDT治疗，分析其疗效与年龄、性别、部位、治疗时间和PDL治疗史的相关性。结果:HMME-PDT在不同年龄、部位、不同既往PDL治疗次数的患者中，疗效在1/2/ 1次后持续存在显著差异(p)。结论:我们的研究表明，HMME-PDT治疗PWS有效。既往PDL治疗次数多、年龄大、唇部受累、肢体PWS是Hemoporfin-PDT的不利因素，而多次HMME-PDT治疗可提高疗效和缓解率。此外，应注意环境温度和病灶温度，局部降温可缓解疼痛，但可能影响效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Photodermatology, photoimmunology & photomedicine 医学-皮肤病学

CiteScore

4.40

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is a forum for new information about the direct and distant effects of electromagnetic radiation (ultraviolet, visible and infrared) mediated through skin. The divisions of the editorial board reflect areas of specific interest: aging, carcinogenesis, immunology, instrumentation and optics, lasers, photodynamic therapy, photosensitivity, pigmentation and therapy. Photodermatology, Photoimmunology & Photomedicine includes original articles, reviews, communications and editorials. Original articles may include the investigation of experimental or pathological processes in humans or animals in vivo or the investigation of radiation effects in cells or tissues in vitro. Methodology need have no limitation; rather, it should be appropriate to the question addressed.