Longitudinal Changes and Association of Respiratory Symptoms with Preserved Ratio Impaired Spirometry (PRISm): The Nagahama Study.

IF 6.8 2区 医学 Q1 RESPIRATORY SYSTEM Annals of the American Thoracic Society Pub Date : 2023-11-01 DOI:10.1513/AnnalsATS.202301-050OC
Mariko Kogo, Susumu Sato, Shigeo Muro, Hisako Matsumoto, Natsuko Nomura, Tsuyoshi Oguma, Hironobu Sunadome, Tadao Nagasaki, Kimihiko Murase, Takahisa Kawaguchi, Yasuharu Tabara, Fumihiko Matsuda, Kazuo Chin, Toyohiro Hirai
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Abstract

Rationale: Subjects with preserved ratio impaired spirometry (PRISm) experience increased respiratory symptoms, although they present heterogeneous characteristics. However, the longitudinal changes in these symptoms and respiratory function are not well known. Objectives: To investigate PRISm from the viewpoint of respiratory symptoms in a longitudinal, large-scale general population study. Methods: The Nagahama study included 9,789 inhabitants, and a follow-up evaluation was conducted after 5 years. Spirometry and self-administered questionnaires regarding respiratory symptoms, including prolonged cough, sputum and dyspnea, and comorbidities were conducted. Results: In total, 9,760 subjects were analyzed, and 438 subjects had PRISm. Among the subjects with PRISm, 53% presented with respiratory symptoms; dyspnea was independently associated with PRISm. Follow-up assessment revealed that 73% of the subjects with PRISm with respiratory symptoms were consistently symptomatic, whereas 39% of the asymptomatic subjects with PRISm developed respiratory symptoms within 5 years. In addition, among subjects with respiratory symptoms without airflow limitation at baseline, PRISm was a risk factor for the development of airflow limitation independent of smoking history and comorbidities. Conclusions: This study demonstrated that 53% of the subjects with PRISm had respiratory symptoms; dyspnea was a distinct characteristic of PRISm. Approximately three-fourths of the symptomatic subjects with PRISm consistently complained of respiratory symptoms within 5 years. Together with our result that PRISm itself is an independent risk factor for the development of chronic obstructive pulmonary disease among subjects with respiratory symptoms, the clinical course of subjects with PRISm with symptoms requires careful monitoring.

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呼吸系统症状的纵向变化与保留比率受损肺活量测定法(PRISm)的相关性:Nagahama研究。
理由:保留比率受损肺活量测定(PRISm)受试者的呼吸道症状增加,尽管他们表现出异质性特征。然而,这些症状和呼吸功能的纵向变化尚不清楚。目的:在一项纵向、大规模的普通人群研究中,从呼吸道症状的角度研究PRISm。方法:长滨研究包括9789名居民,5年后进行随访评估 年。对呼吸系统症状(包括长期咳嗽、痰液和呼吸困难)和合并症进行了肺活量测定和自我管理问卷调查。结果:总共分析了9760名受试者,438名受试人患有PRISm。PRISm受试者中,53%出现呼吸道症状;呼吸困难与PRISm独立相关。随访评估显示,73%的有呼吸道症状的PRISm受试者症状持续,而39%的无症状PRISm患者在5天内出现呼吸道症状 年。此外,在基线时有呼吸系统症状但无气流受限的受试者中,PRISm是气流受限发展的一个危险因素,与吸烟史和合并症无关。结论:本研究表明,53%的PRISm受试者有呼吸道症状;呼吸困难是PRISm的明显特征。大约四分之三的PRISm症状受试者在5天内一直抱怨有呼吸道症状 年。结合我们的研究结果,即PRISm本身是有呼吸道症状的受试者发展为慢性阻塞性肺病的独立风险因素,有症状的PRISm受试者的临床过程需要仔细监测。
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来源期刊
Annals of the American Thoracic Society
Annals of the American Thoracic Society Medicine-Pulmonary and Respiratory Medicine
CiteScore
9.30
自引率
3.60%
发文量
0
期刊介绍: The Annals of the American Thoracic Society (AnnalsATS) is the official international online journal of the American Thoracic Society. Formerly known as PATS, it provides comprehensive and authoritative coverage of a wide range of topics in adult and pediatric pulmonary medicine, respiratory sleep medicine, and adult medical critical care. As a leading journal in its field, AnnalsATS offers up-to-date and reliable information that is directly applicable to clinical practice. It serves as a valuable resource for clinical specialists, supporting their formative and continuing education. Additionally, the journal is committed to promoting public health by publishing research and articles that contribute to the advancement of knowledge in these fields.
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