Piège diagnostique : neurotoxicité au lithium avec lithémie normale

IF 0.7 4区 医学 Q4 UROLOGY & NEPHROLOGY Nephrologie & Therapeutique Pub Date : 2022-12-01 DOI:10.1016/j.nephro.2022.07.398
Hugo Tiv , Antoine Vandelaer , Pierre Delanaye , Florence Forte , Antoine Bouquegneau
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引用次数: 1

Abstract

We describe here the case of a 54-year-old bipolar woman, followed in psychiatry and treated with lithium and a selective serotonin reuptake inhibitor (escitalopram) and lamotrigine, presenting a lithium poisoning with an altered state of consciousness caused by a supposed mismanagement of her treatment. Lithium poisoning was suggested based on neurological clinical features, but the blood test brought out a lithium concentration within the therapeutic values at 1,2 mmol/L (N: 0,6–1,2 mmol/L). The classic biological complications related to lithium poisoning (hypercalcemia, diabetes insipidus) confirmed the diagnosis. The patient has been transferred to our nephrology department where she got two hemodialysis sessions conducting to clinical and biological improvement, confirming the diagnosis of lithium poisoning despite the normal blood levels. Later, she was transferred to the psychiatry department for follow-up and for treatment adjustment.

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诊断陷阱:正常锂血症的锂神经毒性
我们在此描述一位54岁的躁郁症女性,在精神病学中接受了锂和选择性血清素再摄取抑制剂(艾司西酞普兰)和拉莫三嗪的治疗,由于治疗管理不善,她出现了锂中毒并改变了意识状态。根据神经学临床特征推测为锂中毒,但血液检查显示锂浓度在治疗值范围内1.2 mmol/L (N: 0,6 - 1,2 mmol/L)。与锂中毒相关的经典生物学并发症(高钙血症、尿崩症)证实了这一诊断。患者已转至我科肾内科进行了两次血液透析,经临床和生物学改善,在血液水平正常的情况下确诊为锂中毒。后转精神科随访调整治疗。
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来源期刊
Nephrologie & Therapeutique
Nephrologie & Therapeutique 医学-泌尿学与肾脏学
CiteScore
0.80
自引率
14.30%
发文量
485
审稿时长
11.9 weeks
期刊介绍: Organe d''expression de la Société de Néphrologie, de la Société Francophone de Dialyse et de la Société de Néphrologie Pédiatrique, Néphrologie et Thérapeutique a pour vocation de publier des textes en français dans le domaine de la Néphrologie, qu''il s''agisse d''actualisation des connaissances, de recommandations de bonne pratique clinique, de publications originales, ou d''informations sur la vie des trois sociétés fondatrices. La variété des thèmes abordés reflète la richesse de la Néphrologie, qu''il s''agisse d''aspects fondamentaux issus de la physiologie, de l''immunologie, de l''anatomo-pathologie, ou de la génétique, ou de sujets de néphrologie clinique, notamment ceux en rapport avec les thérapeutiques néphrologiques, transplantation, hémodialyse et dialyse péritonéale.
期刊最新文献
Posters Posters commentés Communications orales [Biological parameters for assessment and monitoring anemia in hemodialysis patients]. [Arguments for the use of cardiac biomarkers in hemodialysis: natriuretic peptides and troponins].
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