Effects of Pregnant Fatigue on the Development of Offspring in Rats.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.1177/10998004221124310

Fan Wu, Ting Bai, Shuhan Yan, Feng Zhang

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Abstract

Aim: To explore the correlation between pregnant fatigue and intrauterine physical and neural development of offspring in rats.

Methods: Sprague-Dawley pregnant rats were randomly divided into a normal control group, a mild fatigue group (stand in water for 6 hours/day), and a severe fatigue group (stand in water for 15 h/day). The levels of lactic acid, 5-Hydroxytryptamine and Interleukin-6 in cardiac serum of rats were used to evaluate the fatigue. The expression of S100β in the telencephalon, Insulin-like growth factor-1 (IGF-1) in the liver and Cyclooxygenage-2 (COX-2) in the small intestine tissues of fetal rats were examined. Frozen sections were taken from the telencephalon of rat pups to observe morphological changes in the hippocampal primordium.

Results: Pregnant fatigue led to a decrease in food intake (F = 37.586, p = 0.000) and water intake (F = 23.608, p = 0.000) in rats. The IGF-1 mRNA expression of fetal rats in the severe fatigue group was lower than that in the control group (p = 0.0003). The expression of S100β mRNA (p = 0.000) and COX-2 mRNA (p = 0.0002) of fetal rats were higher in the severe fatigue group than in the control group. HE staining of the telencephalon of fetal rats in the pregnant fatigue group revealed sparse and irregular cell arrangement and increased gaps in the hippocampal primordial site.

Conclusion: Pregnant fatigue rats had both physical fatigue and mental fatigue. Fatigue during pregnancy affects physical development and neurodevelopment of offspring. Further research should elucidate the mechanisms of pregnant fatigue and its effects on offspring.

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妊娠疲劳对大鼠子代发育的影响。

目的:探讨妊娠疲劳与大鼠子代宫内生理和神经发育的关系。方法:将Sprague-Dawley孕鼠随机分为正常对照组、轻度疲劳组(水中站立6小时/天)和重度疲劳组(水中站立15小时/天)。采用乳酸、5-羟色胺、白细胞介素-6等指标评价大鼠心脏血清的疲劳程度。检测胎儿大鼠脑端S100β、肝脏胰岛素样生长因子-1 (IGF-1)和小肠环氧合酶-2 (COX-2)的表达。取大鼠幼鼠端脑冷冻切片，观察海马原基的形态学变化。结果:妊娠疲劳导致大鼠进食量(F = 37.586, p = 0.000)和饮水量(F = 23.608, p = 0.000)减少。重度疲劳组胎鼠IGF-1 mRNA表达量低于对照组(p = 0.0003)。重度疲劳组胎鼠S100β mRNA (p = 0.000)和COX-2 mRNA (p = 0.0002)的表达均高于对照组。妊娠疲劳组胎鼠端脑HE染色显示海马原始区细胞排列稀疏不规则，间隙增多。结论:妊娠疲劳大鼠存在躯体疲劳和精神疲劳。孕期疲劳会影响后代的身体发育和神经发育。进一步的研究应阐明妊娠疲劳的机制及其对后代的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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