Potential Contribution of Hypertension to Evolution of Chronic Migraine and Related Mechanisms.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2022-01-01 Epub Date: 2022-11-28 DOI:10.11607/ofph.3174
Matteo Cotta Ramusino, Giulia Perini, Marco Capelli, Gloria Vaghi, Roberto Fogari, Daniele Bosone, Alfredo Costa
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Abstract

Aims: To investigate the potential contributions of diastolic and systolic blood pressure (BP) and the circadian rhythm of BP to chronic migraine evolution.

Methods: This cross-sectional study included four groups of patients selected based on migraine frequency (high frequency ≥ 10 days per month and low frequency < 10) and on the presence of hypertension. Among-group and pairwise comparisons were carried out to investigate potential neurophysiologic differences in the cerebral vessel reactivity to a nitroglycerin test, in autonomic balance (tilting test), and BP circadian rhythm.

Results: A more marked decrease in cerebral blood flow velocity was observed in hypertensive high-frequency migraineurs compared to all other groups (P = .037). Moreover, a smaller decrease in vagal tone was recorded in the orthostatic position in hypertensive subjects, whether they were high- (P = .032) or low-frequency migraineurs (P = .014), with a consistently higher vagal to sympathetic tone ratio (P = .033). Finally, in nonhypertensive subjects, a higher but not significant prevalence of systolic nondippers was detected in high-frequency migraineurs (67%) compared to low-frequency subjects (25%; P = .099).

Conclusion: These findings suggest that hypertension may contribute to the chronic evolution of headache with mechanisms shared with migraine; ie, vascular tone alteration and autonomic dysregulation.

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高血压对慢性偏头痛演变的潜在贡献及其相关机制。
目的:探讨舒张压和收缩压(BP)及其昼夜节律对慢性偏头痛演变的潜在贡献。方法:本横断面研究包括根据偏头痛频率(高频≥每月10天,低频< 10天)和是否存在高血压选择的四组患者。通过组间比较和两两比较来研究脑血管对硝酸甘油试验的反应性、自主神经平衡(倾斜试验)和血压昼夜节律的潜在神经生理差异。结果:与其他各组相比,高血压高频偏头痛患者脑血流速度下降更为明显(P = 0.037)。此外,无论是高频率偏头痛(P = 0.032)还是低频率偏头痛(P = 0.014),高血压患者在直立体位时迷走神经张力下降较小,迷走神经与交感神经张力比始终较高(P = 0.033)。最后,在非高血压受试者中,高频偏头痛患者(67%)比低频偏头痛患者(25%;P = .099)。结论:高血压可能参与了头痛的慢性演变,其机制与偏头痛相同;即血管张力改变和自主神经失调。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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