Determination of Factors Affecting Time in Therapeutic Range in Patients on Warfarin Therapy.

IF 1.9 4区医学 Q2 NURSING Biological research for nursing Pub Date : 2023-01-01 DOI:10.1177/10998004221127977

Sevda Turen, Selahattin Turen

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Abstract

Background: The effectiveness and safety of warfarin depend on maintaining an international normalized ratio (INR) within the therapeutic range. Time in Therapeutic Range (TTR) is defined as the percentage of time a patient's INR is within the therapeutic range.

Objective: We sought to determine the factors affecting good TTR in patients on warfarin therapy.

Methods: This was a descriptive cross-sectional study conducted in a single tertiary care center. Good anticoagulation control was defined as TTR ≥65%.

Results: The study population consisted of 518 patients. The mean age was 57.6 ± 12.3 (19-87) and 54.4% of the patients were female. 47.5% patients achieved good anticoagulation control (TTR ≥65%). The mean Medication Adherence Report Scale (MARS) score was significantly higher in patients with good TTR (23.5 ± 1.9 vs. 22.8 ± 2.1, p = .002). Only 40.2% of the patients received education on warfarin. In multivariable analyses, the duration of warfarin therapy >10 years (OR: 2.27, 95% CI: 1.34-3.84, p = .002) and MARS score (OR: 1.22, 95% CI: 1.09-1.35, p < .001) were found to be the independent predictors of the good anticoagulation control.

Conclusion: Duration of warfarin therapy >10 years and MARS score were the independent predictors of good anticoagulation control.

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华法林治疗范围内时间影响因素的测定。

背景:华法林的有效性和安全性取决于在治疗范围内维持国际标准化比值(INR)。治疗范围内时间(TTR)定义为患者的INR在治疗范围内的时间百分比。目的:我们试图确定影响华法林治疗患者良好TTR的因素。方法:这是一项描述性横断面研究，在单一三级保健中心进行。以TTR≥65%为抗凝控制良好。结果:研究人群包括518例患者。平均年龄57.6±12.3(19-87)岁，女性占54.4%。47.5%患者抗凝控制良好(TTR≥65%)。TTR良好的患者的平均用药依从性报告量表(MARS)评分显著高于前者(23.5±1.9比22.8±2.1,p = 0.002)。仅有40.2%的患者接受了华法林相关知识的教育。在多变量分析中，华法林治疗持续时间>10年(OR: 2.27, 95% CI: 1.34-3.84, p = 0.002)和MARS评分(OR: 1.22, 95% CI: 1.09-1.35, p < 0.001)是抗凝控制良好的独立预测因子。结论:华法林治疗持续时间>10年和MARS评分是抗凝控制良好的独立预测指标。

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来源期刊

Biological research for nursing 医学-护理

CiteScore

5.10

自引率

4.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biological Research For Nursing (BRN) is a peer-reviewed quarterly journal that helps nurse researchers, educators, and practitioners integrate information from many basic disciplines; biology, physiology, chemistry, health policy, business, engineering, education, communication and the social sciences into nursing research, theory and clinical practice. This journal is a member of the Committee on Publication Ethics (COPE)