Association between the cashmere production performance, milk production performance, and body size traits and polymorphism of COL6A5 and LOC102181374 genes in Liaoning cashmere goats.

IF 1.7 3区农林科学 Q2 AGRICULTURE, DAIRY & ANIMAL SCIENCE Animal Biotechnology Pub Date : 2023-12-01 Epub Date: 2022-12-17 DOI:10.1080/10495398.2022.2155177

Yu Zhang, Yuting Qin, Ming Gu, Yanan Xu, Xingtang Dou, Di Han, Guangyu Lin, Lingling Wang, Zhanhong Wang, Jiaming Wang, Yinggang Sun, Yanzhi Wu, Rui Chen, Yanjun Qiao, Qiu Zhang, Qian Li, Xiaowei Wang, Zhiguo Xu, Yuyan Cong, Jing Chen, Zeying Wang

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Abstract

The purpose of this study was to analyze the relationship between COL6A5 (collagen type VI alpha 5 chain) and LOC102181374 (alcohol dehydrogenase 1) genes and the production performance of Liaoning cashmere goats by single nucleotide polymorphism (SNP). We have searched for SNP loci of COL6A5 and LOC102181374 genes through sequence alignment and PCR experiments, and have used SPSS and SHEsis software to analyze production data. We obtained five SNP loci in total, including three SNP loci (G50985A, G51140T, G51175A) in COL6A5 gene and two SNP loci (A10067G, T10108C) in LOC102181374 gene. The genotypes G50985A (AG), G51140T (GT), G51175A (AA), A10067G (AA), and T10108C (CC) of these loci have certain advantages in improving the production performance of Liaoning cashmere goats. The haplotype combinations that can improve production performance in COL6A5 gene were H1H5:AGGGAG, H4H4:GGGGAA, and H4H4:GGGGAA. H3H3:GGCC and H2H4:AGTT were the dominant combinations in LOC102181374 gene. At G51175A and A10067G loci, we found that H1H2:AAAG and H1H3:AGAA have dominant effects. These results may provide some support for the molecular breeding of production traits in Liaoning cashmere goats.

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辽宁羊绒山羊的羊绒生产性能、产奶量、体型等性状与 COL6A5 和 LOC102181374 基因多态性的关系

本研究旨在通过单核苷酸多态性（SNP）分析COL6A5（Ⅵ型胶原α5链）和LOC102181374（醇脱氢酶1）基因与辽宁羊绒山羊生产性能的关系。我们通过序列比对和 PCR 实验寻找 COL6A5 和 LOC102181374 基因的 SNP 位点，并使用 SPSS 和 SHEsis 软件分析生产数据。共获得 5 个 SNP 位点，包括 COL6A5 基因的 3 个 SNP 位点（G50985A、G51140T、G51175A）和 LOC102181374 基因的 2 个 SNP 位点（A10067G、T10108C）。这些位点的基因型 G50985A (AG)、G51140T (GT)、G51175A (AA)、A10067G (AA) 和 T10108C (CC) 对提高辽宁羊绒山羊的生产性能具有一定的优势。COL6A5 基因中能提高生产性能的单倍型组合为 H1H5:AGGGAG、H4H4:GGGGAA、H4H4:GGGGAA。H3H3:GGCC 和 H2H4:AGTT 是 LOC102181374 基因的优势组合。在 G51175A 和 A10067G 基因位点，我们发现 H1H2:AAAG 和 H1H3:AGAA 具有显性效应。这些结果可为辽宁绒山羊生产性状的分子育种提供一些支持。

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来源期刊

Animal Biotechnology 工程技术-奶制品与动物科学

CiteScore

2.90

自引率

5.40%

发文量

230

审稿时长

>12 weeks

期刊介绍： Biotechnology can be defined as any technique that uses living organisms (or parts of organisms like cells, genes, proteins) to make or modify products, to improve plants, animals or microorganisms for a specific use. Animal Biotechnology publishes research on the identification and manipulation of genes and their products, stressing applications in domesticated animals. The journal publishes full-length articles and short research communications, as well as comprehensive reviews. The journal also provides a forum for regulatory or scientific issues related to cell and molecular biology applied to animal biotechnology. Submissions on the following topics are particularly welcome: - Applied microbiology, immunogenetics and antibiotic resistance - Genome engineering and animal models - Comparative genomics - Gene editing and CRISPRs - Reproductive biotechnologies - Synthetic biology and design of new genomes