Cerebral Sinovenous Thrombosis in Infants and Children: A Practical Approach to Management

IF 2.4 4区 医学 Q2 CLINICAL NEUROLOGY Seminars in Pediatric Neurology Pub Date : 2022-12-01 DOI:10.1016/j.spen.2022.100993
Noa Mandel-Shorer , Christine A. Sabapathy , Pradeep Krishnan , Mukta Sharma , Neil A. Goldenberg , Leonardo R. Brandão , Mahendranath D. Moharir
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引用次数: 1

Abstract

Cerebral sinovenous thrombosis (CSVT) is a rare, yet potentially devastating disorder, associated with acute complications and long-term neurologic sequelae. Consensus-based international pediatric CSVT treatment guidelines emphasize early clinical-radiologic recognition and prompt consideration for anticoagulation therapy. However, lack of clinical trials has precluded evidence-based patient selection, anticoagulant choice, optimal monitoring parameters and treatment duration. Consequently, uncertainties and controversies persist regarding anticoagulation practices in pediatric CSVT. This review focuses on commonly encountered issues that continue to pose questions and raise debates regarding anticoagulation therapy among pediatric neurologists and hematologists.

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婴幼儿脑静脉血栓形成:一种实用的治疗方法
脑静脉血栓形成(CSVT)是一种罕见的,但潜在的破坏性疾病,与急性并发症和长期神经系统后遗症有关。基于共识的国际儿科CSVT治疗指南强调早期临床-放射学识别和及时考虑抗凝治疗。然而,缺乏临床试验妨碍了循证患者选择、抗凝剂选择、最佳监测参数和治疗时间。因此,关于儿科CSVT抗凝实践的不确定性和争议持续存在。这篇综述的重点是儿科神经学家和血液学家在抗凝治疗方面经常遇到的问题和争论。
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来源期刊
Seminars in Pediatric Neurology
Seminars in Pediatric Neurology CLINICAL NEUROLOGY-PEDIATRICS
CiteScore
4.80
自引率
0.00%
发文量
38
审稿时长
84 days
期刊介绍: Seminars in Pediatric Neurology is a topical journal that focuses on subjects of current importance in the field of pediatric neurology. The journal is devoted to making the status of such topics and the results of new investigations readily available to the practicing physician. Seminars in Pediatric Neurology is of special interest to pediatric neurologists, pediatric neuropathologists, behavioral pediatricians, and neurologists who treat all ages.
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