HIV viremia contributes to neurocognitive impairments in persons who use cocaine.

IF 2.3 4区 医学 Q3 NEUROSCIENCES Journal of NeuroVirology Pub Date : 2023-06-01 Epub Date: 2023-03-01 DOI:10.1007/s13365-022-01100-4
Kareem Al-Khalil, Sheri L Towe, Taylor P Ikner, Christina S Meade
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Abstract

Persons with HIV (PWH) who use illicit drugs are at elevated risk for neurocognitive impairment (NCI). This study investigated the effects of HIV disease and HIV viremia on NCI among adults who use cocaine. PWH who were not virologically suppressed showed greater global deficits compared to participants with HIV viral suppression and HIV-negative participants, but no differences emerged between the latter two groups. These findings highlight the adverse effects of poorly controlled HIV disease on NCI, beyond the independent effects of cocaine on cognition, and underscore the importance of strengthening the HIV care continuum for persons who use cocaine.

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艾滋病毒病毒血症导致使用可卡因者的神经认知障碍。
使用非法药物的艾滋病病毒感染者(PWH)罹患神经认知障碍(NCI)的风险较高。本研究调查了艾滋病毒疾病和艾滋病毒病毒血症对吸食可卡因的成年人神经认知障碍的影响。与艾滋病毒病毒抑制的参与者和艾滋病毒阴性的参与者相比,未被病毒抑制的吸毒者表现出更大的全面缺陷,但后两组之间没有差异。除了可卡因对认知的独立影响外,这些研究结果还强调了控制不佳的艾滋病毒疾病对NCI的不利影响,并强调了加强对使用可卡因者的持续艾滋病毒护理的重要性。
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来源期刊
Journal of NeuroVirology
Journal of NeuroVirology 医学-病毒学
CiteScore
6.60
自引率
3.10%
发文量
77
审稿时长
6-12 weeks
期刊介绍: The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects. The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.
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