Detection of human adenovirus among Iranian pediatric hospitalized patients suspected of COVID-19: epidemiology and comparison of clinical features.

Q2 Medicine Infezioni in Medicina Pub Date : 2022-01-01 DOI:10.53854/liim-3004-11
Mohsen Mohammadi, Shadi Bid-Hendi, Mahnaz Baghershiroodi, Mohammad Chehrazi, Yousef Yahyapour, Azin Gouranourimi, Farzin Sadeghi
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引用次数: 3

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children typically results in similar symptoms with other viral respiratory agents including human adenoviruses (HAdVs). Mixed HAdV and SARS-CoV-2 infection (co-infection) in children might result in enhanced or reduced disease severity compared with single infections. The present study aims to investigate the rate of SARS-CoV2 and HAdV infection and also their coinfection and compare the two infections regarding their laboratory and clinical characteristics at hospital admission. A total of 360 combined oropharyngeal and nasopharyngeal swab samples from hospitalized children were examined by real-time PCR for the existence of the SARS-CoV-2 and HAdVs. The symptoms, the clinical characteristics and laboratory findings were retrieved and compared in SARS-CoV-2 and HAdVs positive cases. Of the total 360 suspected COVID-19 hospitalized children, 45 (12.5%) and 19 (5.3%) specimens were PCR-positive for SARS-CoV-2 and HAdV respectively. SARS-CoV-2 and HAdV co-infection was detected in 4 cases (1.1%). Regarding symptoms at hospital admission, fever in SARS-CoV-2 positive group was significantly higher than that in HAdV positive group [34 (85%) vs. 7 (46.7%), p = 0.012]. However, percentages of cases with sore throat, headache, fatigue, lymphadenopathy and conjunctivitis in HAdV positive group were significantly higher than those in SARS-CoV-2 positive group. SARS-CoV-2 and HAdV co-infected children showed mild respiratory symptoms. The present study revealed that SARS-CoV-2 positive children often appear to have a milder clinical course than children with respiratory HAdV infection and children co-infected with SARSCoV-2 and HAdV had less-severe disease on presentation.

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伊朗疑似COVID-19儿科住院患者人腺病毒检测:流行病学及临床特征比较
儿童感染严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)通常会导致与其他呼吸道病毒(包括人腺病毒(HAdVs))类似的症状。与单一感染相比,儿童hav和SARS-CoV-2混合感染(合并感染)可能导致疾病严重程度增强或降低。本研究旨在调查SARS-CoV2和hav的感染率及其合并感染情况,并比较两种感染在入院时的实验室和临床特征。采用实时荧光定量PCR检测住院儿童360份口咽和鼻咽联合拭子样本是否存在SARS-CoV-2和hadv。检索SARS-CoV-2和HAdVs阳性病例的症状、临床特征和实验室检查结果进行比较。360例疑似住院儿童中,SARS-CoV-2 pcr阳性45例(12.5%),hav pcr阳性19例(5.3%)。SARS-CoV-2和hav合并感染4例(1.1%)。入院症状方面,SARS-CoV-2阳性组发热明显高于hav阳性组[34例(85%)比7例(46.7%),p = 0.012]。然而,hav阳性组出现喉咙痛、头痛、疲劳、淋巴结病和结膜炎的比例明显高于SARS-CoV-2阳性组。SARS-CoV-2和hav合并感染患儿表现为轻度呼吸道症状。本研究显示,SARS-CoV-2阳性儿童的临床病程往往比呼吸道hav感染儿童轻,同时感染SARS-CoV-2和hav的儿童在就诊时病情较轻。
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来源期刊
Infezioni in Medicina
Infezioni in Medicina Medicine-Infectious Diseases
CiteScore
8.40
自引率
0.00%
发文量
62
期刊介绍: The Journal publishes original papers, in Italian or in English, on topics concerning aetiopathogenesis, prevention, epidemiology, diagnosis, clinical features and therapy of infections, whose acceptance is subject to the referee’s assessment. The Journal is of interest not only to infectious disease specialists, microbiologists and pharmacologists, but also to internal medicine specialists, paediatricians, pneumologists, and to surgeons as well. The Editorial Board includes experts in each of the above mentioned fields.
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