Fetal pulmonary artery Doppler parameters in pregnancies complicated with intrahepatic cholestasis of pregnancy: a prospective case-control study

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY Journal of the Turkish German Gynecological Association Pub Date : 2022-12-08 DOI:10.4274/jtgga.galenos.2021.2021-9-21

Betül Yakıştıran, Atakan Tanaçan, Orhan Altınboğa, Sarkhan Elbayiyev, Fuat Emre Canpolat, Aykan Yücel

{"title":"Fetal pulmonary artery Doppler parameters in pregnancies complicated with intrahepatic cholestasis of pregnancy: a prospective case-control study","authors":"Betül Yakıştıran, Atakan Tanaçan, Orhan Altınboğa, Sarkhan Elbayiyev, Fuat Emre Canpolat, Aykan Yücel","doi":"10.4274/jtgga.galenos.2021.2021-9-21","DOIUrl":null,"url":null,"abstract":"Objective: The primary aim of this study was to determine whether pulmonary artery acceleration time (AT) to ejection time (ET) ratio (PATET) was altered in fetuses of mothers with intrahepatic cholestasis of pregnancy (IHCP). The secondary aim was to investigate the association between fetal pulmonary artery Doppler parameters with neonatal outcomes in pregnancies complicated by IHCP.Material and methods: This prospective case control study was conducted in a tertiary perinatal-neonatal center. A total of 18 fetuses whose mothers’ pregnancies were complicated by IHCP were included as the study group and a total of 37 fetuses of mothers with healthy pregnancies were selected as controls. Fetal pulmonary artery Doppler parameters (AT; ET; AT/ET ratio) were assessed and neonatal outcomes were evaluated.Results: Mean pulmonary artery AT, ET and PATET were significantly different between the groups (p=0.001, p=0.024 and p=0.003, respectively). The mean PATET value in the IHCP group was 0.217±0.029 while in the control group it was 0.180±0.020. While PATET values were correlated with gestational age at birth, respiratory distress and need for neonatal intensive care admission were not correlated with PATET.Conclusion: Higher values of PATET may be a useful biomarker of fetal lung damage, secondary to IHCP.","PeriodicalId":17440,"journal":{"name":"Journal of the Turkish German Gynecological Association","volume":"23 4","pages":"249-254"},"PeriodicalIF":1.2000,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6e/bd/JTGGA-23-249.PMC9743351.pdf","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the Turkish German Gynecological Association","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4274/jtgga.galenos.2021.2021-9-21","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 1

Abstract

Objective: The primary aim of this study was to determine whether pulmonary artery acceleration time (AT) to ejection time (ET) ratio (PATET) was altered in fetuses of mothers with intrahepatic cholestasis of pregnancy (IHCP). The secondary aim was to investigate the association between fetal pulmonary artery Doppler parameters with neonatal outcomes in pregnancies complicated by IHCP.

Material and methods: This prospective case control study was conducted in a tertiary perinatal-neonatal center. A total of 18 fetuses whose mothers’ pregnancies were complicated by IHCP were included as the study group and a total of 37 fetuses of mothers with healthy pregnancies were selected as controls. Fetal pulmonary artery Doppler parameters (AT; ET; AT/ET ratio) were assessed and neonatal outcomes were evaluated.

Results: Mean pulmonary artery AT, ET and PATET were significantly different between the groups (p=0.001, p=0.024 and p=0.003, respectively). The mean PATET value in the IHCP group was 0.217±0.029 while in the control group it was 0.180±0.020. While PATET values were correlated with gestational age at birth, respiratory distress and need for neonatal intensive care admission were not correlated with PATET.

Conclusion: Higher values of PATET may be a useful biomarker of fetal lung damage, secondary to IHCP.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

妊娠合并肝内胆汁淤积的胎儿肺动脉多普勒参数:一项前瞻性病例对照研究

目的:本研究的主要目的是确定妊娠肝内胆汁淤积(IHCP)母亲的胎儿肺动脉加速时间(AT)与射血时间(ET)之比(PATET)是否发生改变。第二个目的是研究妊娠合并IHCP时胎儿肺动脉多普勒参数与新生儿结局的关系。材料和方法:本前瞻性病例对照研究在三级围产期新生儿中心进行。研究对象为妊娠合并IHCP母亲的18例胎儿，对照组为健康妊娠母亲的37例胎儿。胎儿肺动脉多普勒参数;等;评估AT/ET比率)，并评估新生儿结局。结果:平均肺动脉AT、ET、PATET组间差异有统计学意义(p=0.001、p=0.024、p=0.003)。IHCP组平均PATET值为0.217±0.029，对照组平均PATET值为0.180±0.020。虽然PATET值与出生胎龄相关，但呼吸窘迫和新生儿重症监护入院需求与PATET无关。结论:较高的PATET值可能是继发于IHCP的胎儿肺损伤的有用生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of the Turkish German Gynecological Association OBSTETRICS & GYNECOLOGY-

CiteScore

2.40

自引率

7.10%

发文量

期刊介绍： Journal of the Turkish-German Gynecological Association is the official, open access publication of the Turkish-German Gynecological Education and Research Foundation and Turkish-German Gynecological Association and is published quarterly on March, June, September and December. It is an independent peer-reviewed international journal printed in English language. Manuscripts are reviewed in accordance with “double-blind peer review” process for both reviewers and authors. The target audience of Journal of the Turkish-German Gynecological Association includes gynecologists and primary care physicians interested in gynecology practice. It publishes original works on all aspects of obstertrics and gynecology. The aim of Journal of the Turkish-German Gynecological Association is to publish high quality original research articles. In addition to research articles, reviews, editorials, letters to the editor, diagnostic puzzle are also published. Suggestions for new books are also welcomed. Journal of the Turkish-German Gynecological Association does not charge any fee for article submission or processing.