Relationship between CYP2C19 Polymorphism and Clopidogrel Resistance in Patients with Coronary Heart Disease and Ischemic Stroke in China.

IF 1.4 4区生物学 Q4 GENETICS & HEREDITY Genetics research Pub Date : 2022-01-01 DOI:10.1155/2022/1901256

Rong Chang, Wenqin Zhou, Yi Ye, Xiaofei Zhang, Yanmin Liu, Jinchun Wu

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引用次数: 1

Abstract

Objective: Clopidogrel is widely used for preventing ischemic complications related to cardiovascular diseases. However, many patients experience clopidogrel resistance (CR). The polymorphisms of CYP2C19 have been implicated in CR, but CYP2C19 polymorphism considerably varies with both ethnic group and geographical location. This study aimed to investigate the association between CYP2C19 polymorphisms and clopidogrel resistance (CR) in patients with coronary heart disease and ischemic stroke among Han and Tibetan populations in Qinghai Province, China.

Methods: From June 2019 to January 2020, patients who were diagnosed with coronary heart disease or cerebral infarction in internal medicine of Qinghai Provincial People's Hospital and had taken dual antiplatelet drugs were included in this study. Blood was collected and routine items were completed. Whole exome sequencing was performed for CYP2C19 genetic polymorphisms of CYP2C19∗2 (rs4244285), CYP2C19∗3 (rs4986893), and CYP2C19∗17 (rs12248560).

Results: A total of 91 patients with coronary heart disease or cerebral infarction (67 Han people (65.99 ± 12.25 years old) and 24 Tibetan (63.6324 Tib years old)) including 52 cases with CR and 39 cases with non-CR were enrolled in this study. For the Han population, the differences in age, glycosylated hemoglobin, activated partial thromboplastin time (APTT), gender, aspirin resistance, and diabetes were significant between the CR and non-CR groups. For the Tibetan population, the two groups showed no significant difference in all indicators. There was no significant difference between CR and non-CR groups for all genotypes (CYP2C19 ∗2, ∗3, and ∗17) in either Han or Tibetan populations. For the Han populations, age, APTT, and aspirin resistance were significantly correlated with CR.

Conclusion: The present study indicated that CYP2C19∗2, CYP2C19∗3, and CYP2C19∗17 alleles were not correlated with CR for both Han and Tibetan populations in Qinghai Province, while age, APTT, and aspirin resistance were independent risk factors of CR in this region.

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中国冠心病及缺血性脑卒中患者CYP2C19多态性与氯吡格雷耐药的关系

目的:氯吡格雷广泛用于预防心血管疾病相关的缺血性并发症。然而，许多患者经历氯吡格雷抵抗(CR)。CYP2C19的多态性与CR有关，但CYP2C19的多态性在种族和地理位置上有很大差异。本研究旨在探讨青海省汉族和藏族冠心病和缺血性脑卒中患者CYP2C19多态性与氯吡格雷耐药(CR)的关系。方法:选取2019年6月至2020年1月在青海省人民医院内科诊断为冠心病或脑梗死并服用双抗血小板药物的患者为研究对象。采集血液并完成常规项目。对CYP2C19 * 2 (rs4244285)、CYP2C19 * 3 (rs4986893)和CYP2C19 * 17 (rs12248560)的基因多态性进行全外显子组测序。结果:共纳入冠心病或脑梗死患者91例(汉族67例(65.99±12.25岁)，藏族24例(63.6324藏族)，其中CR 52例，非CR 39例。在汉族人群中，CR组和非CR组在年龄、糖化血红蛋白、活化部分凝血活素时间(APTT)、性别、阿司匹林抵抗和糖尿病方面存在显著差异。对于藏族人群，两组在所有指标上均无显著差异。在汉族和藏族人群中，所有基因型(CYP2C19∗2，∗3和∗17)在CR组和非CR组之间均无显著差异。结论:在青海省汉族人群中，CYP2C19∗2、CYP2C19∗3和CYP2C19∗17等位基因与CR均无相关性，而年龄、APTT和阿司匹林耐药性是该地区CR的独立危险因素。

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来源期刊

Genetics research 生物-遗传学

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： Genetics Research is a key forum for original research on all aspects of human and animal genetics, reporting key findings on genomes, genes, mutations and molecular interactions, extending out to developmental, evolutionary, and population genetics as well as ethical, legal and social aspects. Our aim is to lead to a better understanding of genetic processes in health and disease. The journal focuses on the use of new technologies, such as next generation sequencing together with bioinformatics analysis, to produce increasingly detailed views of how genes function in tissues and how these genes perform, individually or collectively, in normal development and disease aetiology. The journal publishes original work, review articles, short papers, computational studies, and novel methods and techniques in research covering humans and well-established genetic organisms. Key subject areas include medical genetics, genomics, human evolutionary and population genetics, bioinformatics, genetics of complex traits, molecular and developmental genetics, Evo-Devo, quantitative and statistical genetics, behavioural genetics and environmental genetics. The breadth and quality of research make the journal an invaluable resource for medical geneticists, molecular biologists, bioinformaticians and researchers involved in genetic basis of diseases, evolutionary and developmental studies.