Atherosclerosis Associated With COVID-19: Acute, Tends to Severely Involve Peripheral Arteries, and May be Reversible.

IF 2.6 3区医学 Q2 PERIPHERAL VASCULAR DISEASE Angiology Pub Date : 2025-01-01 Epub Date: 2023-08-23 DOI:10.1177/00033197231198253

Eman O Mahmoud, Yumn A Elsabagh, Nagwa Abd El Ghaffar, Mary Wadie Fawzy, Mohamed A Hussein

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Abstract

Arterial stiffness was reported with corona virus disease 2019 (COVID-19). We studied atherosclerosis in COVID-19 directly through duplex ultrasound measurements and their relation to co-morbidities, clinical and laboratory severity markers, and serum interleukin (IL) 6 and 17. Serum IL 6 and 17, average carotid intima-media thickness (cIMT), diameter and peak systolic velocities (PSV) of tibial, ulnar, radial arteries, and ankle brachial index (ABI) were measured in 44 COVID-19 patients and 44 healthy controls. Serum IL6, IL17, PSV, and cIMT were higher while diameter was lower (P ≤ .01) in cases. Clinical severity index correlated positively with age, co-morbidities, ferritin, IL6, IL17, cIMT, and PSV (P ≤ .04) and negatively with diameter and ABI (P = .04). Patients with severe lymphopenia had higher PSV, IL6, and IL17 and lower diameter (P < .00001). Ferritin positively correlated with PSV and negatively with diameter and ABI (P ≤ .01). Those who received an IL6 inhibitor (tocilizumab) showed lower PSV and higher diameter (P ≤ .01). In multiple regression analysis, IL17 and (age, co-morbidities) were related to (PSV, diameter) and cIMT (P ≤ .001, ≤0.02), respectively. COVID-19 may be associated with subclinical acute and may be reversible atherosclerosis severely involving peripheral arteries.

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与 COVID-19 有关的动脉粥样硬化：急性，倾向于严重累及外周动脉，并且可能是可逆的。

据报道，2019年冠状病毒病（COVID-19）患者的动脉僵化。我们通过双工超声测量直接研究了 COVID-19 的动脉粥样硬化及其与合并疾病、临床和实验室严重程度指标以及血清白细胞介素（IL）6 和 17 的关系。对 44 名 COVID-19 患者和 44 名健康对照者的血清 IL6 和 IL17、平均颈动脉内膜厚度（cIMT）、胫、尺、桡动脉直径和收缩峰值速度（PSV）以及踝臂指数（ABI）进行了测量。病例的血清 IL6、IL17、PSV 和 cIMT 较高，而直径较低（P ≤ .01）。临床严重程度指数与年龄、合并疾病、铁蛋白、IL6、IL17、cIMT 和 PSV 呈正相关（P ≤ .04），与直径和 ABI 呈负相关（P = .04）。严重淋巴细胞减少症患者的 PSV、IL6 和 IL17 较高，直径较低（P < .00001）。铁蛋白与 PSV 呈正相关，与直径和 ABI 呈负相关（P ≤ .01）。接受 IL6 抑制剂（托西珠单抗）治疗的患者 PSV 更低，直径更大（P ≤ .01）。在多元回归分析中，IL17和（年龄、合并疾病）分别与（PSV、直径）和cIMT相关（P≤.001，≤0.02）。COVID-19可能与严重累及外周动脉的亚临床急性和可逆性动脉粥样硬化有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Angiology 医学-外周血管病

CiteScore

5.50

自引率

14.30%

发文量

180

审稿时长

6-12 weeks

期刊介绍： A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days