Intestinal Amino Acid Transport and Metabolic Health.

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS Annual review of nutrition Pub Date : 2023-08-21 DOI:10.1146/annurev-nutr-061121-094344
Stefan Bröer
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引用次数: 1

Abstract

Amino acids derived from protein digestion are important nutrients for the growth and maintenance of organisms. Approximately half of the 20 proteinogenic amino acids can be synthesized by mammalian organisms, while the other half are essential and must be acquired from the nutrition. Absorption of amino acids is mediated by a set of amino acid transporters together with transport of di- and tripeptides. They provide amino acids for systemic needs and for enterocyte metabolism. Absorption is largely complete at the end of the small intestine. The large intestine mediates the uptake of amino acids derived from bacterial metabolism and endogenous sources. Lack of amino acid transporters and peptide transporter delays the absorption of amino acids and changes sensing and usage of amino acids by the intestine. This can affect metabolic health through amino acid restriction, sensing of amino acids, and production of antimicrobial peptides.

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肠道氨基酸转运与代谢健康。
消化蛋白质产生的氨基酸是生物体生长和维持的重要营养物质。20种蛋白质氨基酸中大约有一半可以由哺乳动物合成,而另一半是必需的,必须从营养中获得。氨基酸的吸收是由一组氨基酸转运蛋白以及二肽和三肽的转运介导的。它们为全身需要和肠细胞代谢提供氨基酸。吸收在小肠末端基本完成。大肠介导来自细菌代谢和内源性来源的氨基酸的摄取。氨基酸转运体和肽转运体的缺乏延迟了氨基酸的吸收,改变了肠道对氨基酸的感知和利用。这可以通过氨基酸限制、氨基酸感知和抗菌肽的产生影响代谢健康。
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来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
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