Enantioselective N-Heterocyclic Carbene-Catalyzed Synthesis of Trifluoromethyldihydropyridinones

IF 3.3 2区 化学 Q1 CHEMISTRY, ORGANIC Journal of Organic Chemistry Pub Date : 2015-05-01 DOI:10.1021/acs.joc.5b00232
Dong-Ling Wang, Zhi-Qin Liang, Kun-Quan Chen, De-Qun Sun*, Song Ye*
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引用次数: 22

Abstract

The enantioselective N-heterocyclic carbene-catalyzed [4 + 2] cyclocondensation of α-chloroaldehydes and trifluoromethyl N-Boc azadienes was developed, giving the corresponding 3,4-disubstituted-6-trifluoromethyldihydropyridin-2(1H)-ones in good yields with exclusive cis-selectivities and excellent enantioselectivities.

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对映选择性n -杂环碳催化合成三氟甲基二氢吡啶酮
研究了α-氯醛与三氟甲基N-Boc偶氮二烯的对映选择性n-杂环碳催化[4 + 2]环缩合反应,得到相应的3,4-二取代-6-三氟甲基二氢吡啶-2(1H)-化合物,产率高,具有独特的顺式选择性和优异的对映选择性。
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来源期刊
Journal of Organic Chemistry
Journal of Organic Chemistry 化学-有机化学
CiteScore
6.20
自引率
11.10%
发文量
1467
审稿时长
2 months
期刊介绍: Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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