Gluconeogenesis Flux in Metabolic Disease.

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS Annual review of nutrition Pub Date : 2023-08-21 DOI:10.1146/annurev-nutr-061121-091507
Ankit Shah, Fredric E Wondisford
{"title":"Gluconeogenesis Flux in Metabolic Disease.","authors":"Ankit Shah, Fredric E Wondisford","doi":"10.1146/annurev-nutr-061121-091507","DOIUrl":null,"url":null,"abstract":"<p><p>Gluconeogenesis is a critical biosynthetic process that helps maintain whole-body glucose homeostasis and becomes altered in certain medical diseases. We review gluconeogenic flux in various medical diseases, including common metabolic disorders, hormonal imbalances, specific inborn genetic errors, and cancer. We discuss how the altered gluconeogenic activity contributes to disease pathogenesis using data from experiments using isotopic tracer and spectroscopy methodologies. These in vitro, animal, and human studies provide insights into the changes in circulating levels of available gluconeogenesis substrates and the efficiency of converting those substrates to glucose by gluconeogenic organs. We highlight ongoing knowledge gaps, discuss emerging research areas, and suggest future investigations. A better understanding of altered gluconeogenesis flux may ultimately identify novel and targeted treatment strategies for such diseases.</p>","PeriodicalId":8009,"journal":{"name":"Annual review of nutrition","volume":null,"pages":null},"PeriodicalIF":12.6000,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of nutrition","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1146/annurev-nutr-061121-091507","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0

Abstract

Gluconeogenesis is a critical biosynthetic process that helps maintain whole-body glucose homeostasis and becomes altered in certain medical diseases. We review gluconeogenic flux in various medical diseases, including common metabolic disorders, hormonal imbalances, specific inborn genetic errors, and cancer. We discuss how the altered gluconeogenic activity contributes to disease pathogenesis using data from experiments using isotopic tracer and spectroscopy methodologies. These in vitro, animal, and human studies provide insights into the changes in circulating levels of available gluconeogenesis substrates and the efficiency of converting those substrates to glucose by gluconeogenic organs. We highlight ongoing knowledge gaps, discuss emerging research areas, and suggest future investigations. A better understanding of altered gluconeogenesis flux may ultimately identify novel and targeted treatment strategies for such diseases.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
代谢性疾病中的糖元生成通量。
糖元生成是一个关键的生物合成过程,有助于维持全身葡萄糖稳态,在某些疾病中会发生改变。我们回顾了各种内科疾病中的糖元生成通量,包括常见的代谢紊乱、激素失衡、特定的先天性遗传错误和癌症。我们将利用同位素示踪和光谱学方法的实验数据,讨论糖元生成活性的改变是如何导致疾病发病的。这些体外、动物和人体研究提供了有关可用糖元生成底物循环水平变化以及糖元生成器官将这些底物转化为葡萄糖的效率的见解。我们强调了目前存在的知识空白,讨论了新兴的研究领域,并对未来的研究提出了建议。更好地了解糖元生成通量的改变,最终可能为这类疾病找到新的靶向治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
期刊最新文献
Adverse Food Reactions: Physiological and Ecological Perspectives. Does Maternal Diet Influence Future Infant Taste and Odor Preferences? A Critical Analysis. Helminth Infections and Diabetes: Mechanisms Accounting for Risk Amelioration. Interactions of Nutrition and Infection: The Role of Micronutrient Deficiencies in the Immune Response to Pathogens and Implications for Child Health. Energy Expenditure in Humans: Principles, Methods, and Changes Throughout the Life Course.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1