COVID-19 chest CT and laboratory features of B.1.617.2 (Delta variant) vs B.1.1.7 (Alpha variant) surge: a single center case-control study.

Q2 Medicine Infezioni in Medicina Pub Date : 2022-01-01 DOI:10.53854/liim-3004-10
Giulio Viceconte, Andrea Ponsiglione, Antonio Riccardo Buonomo, Luigi Camera, Riccardo Scotto, Marco De Giorgi, Lorenzo Pinto, Biagio Pinchera, Riccardo Villari, Maria Foggia, Gerardo Gerundo, Pasquale Abete, Arturo Brunetti, Ivan Gentile
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Abstract

Purpose: To assess clinical, laboratory and radiological differences between Delta and Alpha SARS-CoV-2 variants.

Materials and methods: Twenty SARS-CoV-2 patients admitted from 30th of August to 30th of October 2021 (period with estimated highest prevalence of Delta variant circulation in Italy) were enrolled. Patients were matched in a 1:1 ratio with same gender and same age +/- 2 years controls admitted from 1st of September 2020 to 30th of January 2021 (predominant circulation of Alpha variant). Chest computed tomography (CT) were retrospectively evaluated. Main clinical parameters, radiological and laboratory findings were compared between two groups.

Results: Patients with probable Delta variant had significantly higher CT severity scores, lower PaO2/FiO2 ratio and higher C-reactive protein and lactate dehydrogenase levels at admission. On multivariate analysis, probable Delta variant infection was associated with higher CT severity score. Ground glass opacities and crazy paving patterns were more frequently noticed than consolidation, with the latter being more frequent in Delta cohort, even though not significantly. According to prevalent imaging pattern, the consolidation one was significantly associated with pregnancy (p=0.008).

Conclusions: Patients admitted during predominance of Delta variant circulation had a more severe lung involvement compared to patients in infected when Alpha variant was predominant. Despite imaging pattern seems to be not influenced by viral variant and other clinical variables, the consolidative pattern was observed more frequently in pregnancy.

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B.1.617.2 (δ变异)vs .1.1.7 (α变异)激增的COVID-19胸部CT和实验室特征:一项单中心病例对照研究
目的:评估δ型和α型SARS-CoV-2变体的临床、实验室和放射学差异。材料和方法:纳入了2021年8月30日至10月30日(估计意大利德尔塔变体流行率最高的时期)入院的20例SARS-CoV-2患者。2020年9月1日至2021年1月30日入院的患者与同性别、同年龄+/- 2岁的对照组按1:1比例匹配(主要是α型循环)。回顾性评价胸部计算机断层扫描(CT)。比较两组患者的主要临床参数、影像学及实验室检查结果。结果:可能δ变异患者入院时CT严重程度评分较高,PaO2/FiO2比值较低,c反应蛋白和乳酸脱氢酶水平较高。在多变量分析中,可能的德尔塔变异感染与较高的CT严重程度评分相关。磨砂玻璃不透明和疯狂的铺装模式比合并更常见,后者在Delta队列中更常见,尽管不明显。根据流行的影像学表现,实变型与妊娠有显著相关性(p=0.008)。结论:与α变异为主的感染患者相比,δ变异循环为主的患者肺部受累更严重。尽管成像模式似乎不受病毒变异和其他临床变量的影响,但合并模式在妊娠期间更常见。
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来源期刊
Infezioni in Medicina
Infezioni in Medicina Medicine-Infectious Diseases
CiteScore
8.40
自引率
0.00%
发文量
62
期刊介绍: The Journal publishes original papers, in Italian or in English, on topics concerning aetiopathogenesis, prevention, epidemiology, diagnosis, clinical features and therapy of infections, whose acceptance is subject to the referee’s assessment. The Journal is of interest not only to infectious disease specialists, microbiologists and pharmacologists, but also to internal medicine specialists, paediatricians, pneumologists, and to surgeons as well. The Editorial Board includes experts in each of the above mentioned fields.
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