{"title":"Centrosome Dysfunctions in Cancer.","authors":"Heide Schatten","doi":"10.1007/978-3-031-20848-5_4","DOIUrl":null,"url":null,"abstract":"<p><p>As major accomplishments and breakthroughs in centrosome research had been achieved by Theodor Boveri in reproductive cells with the invertebrate sea urchin being an ideal model system for such studies on fertilization, cell division, and embryo development, these studies also gave rise to Boveri's brilliant concept regarding cancer cells. He discovered that eggs fertilized with two sperm resulted in tripolar mitosis and abnormal cell division, similar to cells observed in cancer tissue.</p>","PeriodicalId":50879,"journal":{"name":"Advances in Anatomy Embryology and Cell Biology","volume":"235 ","pages":"43-50"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Anatomy Embryology and Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1007/978-3-031-20848-5_4","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
As major accomplishments and breakthroughs in centrosome research had been achieved by Theodor Boveri in reproductive cells with the invertebrate sea urchin being an ideal model system for such studies on fertilization, cell division, and embryo development, these studies also gave rise to Boveri's brilliant concept regarding cancer cells. He discovered that eggs fertilized with two sperm resulted in tripolar mitosis and abnormal cell division, similar to cells observed in cancer tissue.
期刊介绍：
"Advances in Anatomy, Embryology and Cell Biology" presents critical reviews on all topical fields of normal and experimental anatomy including cell biology. The multi-perspective presentation of morphological aspects of basic biological phenomen in the human constitutes the main focus of the series. The contributions re-evaluate the latest findings and show ways for further research.
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