Microvascular remodeling following skin injury

IF 1.9 4区医学 Q3 HEMATOLOGY Microcirculation Pub Date : 2022-03-01 DOI:10.1111/micc.12755

Liv Kristin Wikslund, Mari-Liis Kaljusto, Vivian Shubira Amundsen, Knut Kvernebo

引用次数: 2

Abstract

The aim of this study was to describe possible remodeling (i.e., dilatation and elongation) of papillary capillaries induced by increased oxygen demand for the repair process following a skin wound.

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皮肤损伤后微血管重构

目的本研究的目的是描述可能的重塑(即，扩张和伸长)的乳头状毛细血管引起的修复过程中的皮肤伤口增加的氧气需求。方法采用计算机辅助视频显微镜观察10例健康志愿者，分别在距切口0 ~ 1mm和30mm(对照部位)的前臂(长5mm，深1mm)和(≈1h和≈24h)前(基线)和后(≈1h和≈24h)进行检查。我们定义了从0(低)到3(高)到分级的营养乳头状毛细血管的扩张和伸长，以及浅表血管丛的可见性。来自200部电影的大约1万个毛细血管被评分。结果营养性乳头状毛细血管扩张、伸长(p <≈24 h后0.01);即伸长率(评分1.9±0.9)vs基线(评分0.9±0.6)，p <扩张(评分2.2±0.7)vs基线(评分0.3±0.3)，p <0.01. 浅表神经丛可见性增高(p <与基线(0.8±0.4)相比，分别≈1 h(评分2.0±0.7)和≈24 h(评分2.7±0.3)。结论皮肤浅层血管丛在外伤后约1 h可见性增强。营养乳头毛细血管在≈24 h后的形态重塑——扩张和伸长——促进了氧供应的增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microcirculation 医学-外周血管病

CiteScore

5.00

自引率

4.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.