Mucosal melanoma: from molecular landscape to current treatment strategies.

IF 1.5 4区 医学 Q3 DERMATOLOGY Melanoma Research Pub Date : 2023-12-01 Epub Date: 2023-08-25 DOI:10.1097/CMR.0000000000000916
Jane Mattei, Eduardo N Trindade, Marcio F Chedid
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Abstract

Mucosal melanoma (MM) is an aggressive tumor originating from melanocytes located in the respiratory, gastrointestinal, and urogenital tract with clinical and pathologic characteristics distinct from cutaneous melanoma. In addition, MMs have a unique biology that contributes to delayed diagnosis and, therefore an adverse prognosis. The factors all contribute to a treatment paradigm unique from its more studied cutaneous brethren. Due to the rarity of this disease, well-established protocols for the treatment of this pathology have yet to be established. The use of immune checkpoint inhibitors patterned after cutaneous melanoma has become the de facto primary therapeutic approach; however, cytotoxic strategies and pathway-targeted therapies have a defined role in treatment. Judicious use of these approaches can give rise to durable unmaintained disease responses.

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粘膜黑色素瘤:从分子景观到当前的治疗策略。
粘膜黑色素瘤(MM)是一种侵袭性肿瘤,起源于位于呼吸道、胃肠道和泌尿生殖道的黑色素细胞,其临床和病理特征与皮肤黑色素瘤不同。此外,MM具有独特的生物学特性,有助于延迟诊断,从而导致不良预后。这些因素都促成了一种独特的治疗模式,这种模式与更多研究的皮肤同行不同。由于这种疾病的罕见性,尚未建立治疗这种病理的既定方案。使用以皮肤黑色素瘤为模式的免疫检查点抑制剂已成为事实上的主要治疗方法;然而,细胞毒性策略和通路靶向疗法在治疗中具有明确的作用。明智地使用这些方法可以产生持久的未经控制的疾病反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Melanoma Research
Melanoma Research 医学-皮肤病学
CiteScore
3.40
自引率
4.50%
发文量
139
审稿时长
6-12 weeks
期刊介绍: ​​​​​​Melanoma Research is a well established international forum for the dissemination of new findings relating to melanoma. The aim of the Journal is to promote the level of informational exchange between those engaged in the field. Melanoma Research aims to encourage an informed and balanced view of experimental and clinical research and extend and stimulate communication and exchange of knowledge between investigators with differing areas of expertise. This will foster the development of translational research. The reporting of new clinical results and the effect and toxicity of new therapeutic agents and immunotherapy will be given emphasis by rapid publication of Short Communications. ​Thus, Melanoma Research seeks to present a coherent and up-to-date account of all aspects of investigations pertinent to melanoma. Consequently the scope of the Journal is broad, embracing the entire range of studies from fundamental and applied research in such subject areas as genetics, molecular biology, biochemistry, cell biology, photobiology, pathology, immunology, and advances in clinical oncology influencing the prevention, diagnosis and treatment of melanoma.
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