NAFLD Nutritional Management: Results from a Multidisciplinary Approach.

IF 1 Q4 GASTROENTEROLOGY & HEPATOLOGY GE Portuguese Journal of Gastroenterology Pub Date : 2022-11-01 DOI:10.1159/000519932
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引用次数: 2

Abstract

Introduction: Lifestyle changes are the mainstay treatment of nonalcoholic fatty liver disease (NAFLD). We aimed to assess the magnitude of weight loss in a group of NAFLD patients followed on a combined lifestyle intervention by a multidisciplinary team.

Methods: Patients were assessed before and after a 12-month dietary intervention (Mediterranean diet aiming at weight loss). Patients who received a structured dietary plan along with general lifestyle recommendations were designated as the multidisciplinary treatment (MdT) group. Patients who declined follow-up still received general lifestyle recommendations and were designated as the conventional treatment group, being used as a control group.

Results: From the 77 patients with documented NAFLD, 31.2% of patients were overweight and 55.8% obese; 66 patients constituted the MdT group and 11 the conventional treatment group. After 3 months, 89% of patients lost weight; at 6 months, 75.4% maintained the weight lost. At 12 months, 65% of patients still decreased their weight, with 92.2% of patients in the MdT group still maintaining a lower weight than baseline versus just 50% in the conventional group (p = 0.008). Only patients in the MdT group presented a weight loss higher than 10% (9.6%; n = 6). At 12 months patients in the MdT group presented an average reduction of 4.2 kg versus a reduction of just 0.6 kg in the conventional treatment group (p = 0.016). The MdT group, but not the conventional group, presented significant differences in liver enzymes at 12 months compared to baseline.

Conclusion: Adherence to a multidisciplinary approach, compared to management solely by a hepatologist, in NAFLD patients, is effective with greater weight loss after a 12-month follow-up and a lower rate of weight gain recurrence.

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NAFLD营养管理:多学科方法的结果。
生活方式的改变是非酒精性脂肪性肝病(NAFLD)的主要治疗方法。我们的目的是评估一组NAFLD患者在多学科团队联合生活方式干预后体重减轻的程度。方法:对患者进行为期12个月的饮食干预(以减肥为目的的地中海饮食)前后进行评估。接受结构化饮食计划和一般生活方式建议的患者被指定为多学科治疗(MdT)组。拒绝随访的患者仍接受一般生活方式建议,并被指定为常规治疗组,作为对照组。结果:在77例记录在案的NAFLD患者中,31.2%的患者超重,55.8%的患者肥胖;MdT组66例,常规治疗组11例。3个月后,89%的患者体重减轻;6个月后,75.4%的人保持了减肥效果。12个月后,65%的患者体重仍然下降,其中92.2%的MdT组患者体重仍然低于基线,而传统组仅为50% (p = 0.008)。只有MdT组患者体重减轻超过10% (9.6%;n = 6)。在12个月时,MdT组患者平均减少4.2 kg,而传统治疗组仅减少0.6 kg (p = 0.016)。与基线相比,MdT组在12个月时的肝酶有显著差异,而常规组没有。结论:在NAFLD患者中,坚持多学科治疗比单独由肝病专家治疗更有效,随访12个月后体重减轻幅度更大,体重增加复发率更低。
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来源期刊
GE Portuguese Journal of Gastroenterology
GE Portuguese Journal of Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
1.60
自引率
11.10%
发文量
62
审稿时长
21 weeks
期刊介绍: The ''GE Portuguese Journal of Gastroenterology'' (formerly Jornal Português de Gastrenterologia), founded in 1994, is the official publication of Sociedade Portuguesa de Gastrenterologia (Portuguese Society of Gastroenterology), Sociedade Portuguesa de Endoscopia Digestiva (Portuguese Society of Digestive Endoscopy) and Associação Portuguesa para o Estudo do Fígado (Portuguese Association for the Study of the Liver). The journal publishes clinical and basic research articles on Gastroenterology, Digestive Endoscopy, Hepatology and related topics. Review articles, clinical case studies, images, letters to the editor and other articles such as recommendations or papers on gastroenterology clinical practice are also considered. Only articles written in English are accepted.
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