Clinical implications of Cytokeratin 19 expression in patients with oral squamous cell carcinoma.

IF 4.4 Q1 PATHOLOGY PATHOLOGICA Pub Date : 2023-06-01 DOI:10.32074/1591-951X-842
Nur Rahadiani, Sarwanti Sarwanti, Diah Rini Handjari, Marini Stephanie, Ening Krisnuhoni
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Abstract

Objective: This study was done to quantify the prevalence of high cytokeratin (CK) 19 expression in Indonesian oral squamous cell carcinoma (OSCC) patients and explore the prognostic role of CK19 in OSCC.

Methods: Clinical data and samples from 61 patients diagnosed with OSCC at a tertiary national referral hospital in Jakarta, Indonesia were analyzed in this retrospective cohort study. Immunohistochemical staining of CK19 was performed on all patients and its expression was scored using the H system. All patients were followed up for a minimum of 36 months after diagnosis. Comparative and survival analyses were performed.

Results: Twenty six point two percent of Indonesian OSCC patients had high CK19 expression. There were no differences in clinicopathological characteristics between patients with low and high CK19 expression. The 3-year overall survival (OS) of our cohort was 11.5%. Patients with high CK19 expression had lower 3-year OS compared to patients with low CK19 expression, even if the difference in OS was not statistically significant. Keratinization was an independent prognostic factor for survival in multivariate regression analysis.

Conclusions: Data obtained here indicate a possible prognostic role of CK19 in OSCC. This prognostic role should be confirmed in larger series.

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口腔鳞状细胞癌细胞角蛋白19表达的临床意义。
目的:本研究旨在量化印尼口腔鳞状细胞癌(OSCC)患者中细胞角蛋白(CK) 19高表达的患病率,并探讨CK19在OSCC中的预后作用。方法:回顾性队列研究分析了印度尼西亚雅加达一家三级国家转诊医院61例OSCC患者的临床资料和样本。对所有患者进行CK19免疫组化染色,并用H系统对其表达进行评分。所有患者在确诊后至少随访36个月。进行了比较分析和生存分析。结果:26.2%的印尼OSCC患者CK19高表达。CK19低表达与高表达患者的临床病理特征无差异。我们队列的3年总生存率(OS)为11.5%。与CK19低表达患者相比,CK19高表达患者的3年OS较低,即使OS差异无统计学意义。在多变量回归分析中,角化是一个独立的预后因素。结论:本文获得的数据表明CK19在OSCC中可能具有预后作用。这种预后作用应在更大的系列中得到证实。
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来源期刊
PATHOLOGICA
PATHOLOGICA PATHOLOGY-
CiteScore
5.90
自引率
5.70%
发文量
108
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