Reproducibility of each retinal layer thickness measurement in epiretinal membrane patients with ectopic inner foveal layers.

IF 4.1 1区医学 Q1 OPHTHALMOLOGY Eye and Vision Pub Date : 2023-01-04 DOI:10.1186/s40662-022-00321-2

Il Jung, Yong-Jin Na, Sung-Chul Lee, Min-Woo Lee

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Abstract

Background: To identify the reliability of each retinal layer thickness measurement in epiretinal membrane (ERM) patients with ectopic inner foveal layers (EIFLs).

Methods: Subjects were divided into two groups: ERM patients with EIFLs (Group 1) and without EIFLs (Group 2). The retinal layer thickness was measured twice, and intraclass correlation coefficient (ICC) and coefficient of variation (CV) values were calculated.

Results: In Group 1, the CVs of the nerve fiber layer (NFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), and outer nuclear layer (ONL) were 22.39%, 13.12%, 13.37%, 13.21%, 15.09%, and 11.94%, while the ICCs were 0.431, 0.550, 0.440, 0.286, 0.279, and 0.503, respectively. In Group 2, the CVs were 18.20%, 10.59%, 10.65%, 13.27%, 14.75%, and 10.37%, while the ICCs were 0.788, 0.834, 0.830, 0.715, 0.226, and 0.439, respectively. The average central macular thickness (CMT) was significantly correlated with the CVs of NFL (coefficient = 0.317; P < 0.001), GCL (coefficient = 0.328; P < 0.001), and IPL (coefficient = 0.186; P = 0.042) in Group 1.

Conclusions: The reproducibility of the inner retinal layer thickness measurements in ERM patients with EIFLs was low compared to those without EIFLs. The reproducibility of the outer retinal layer thickness measurements, including OPL and ONL, was poor regardless of the presence of EIFLs in ERM patients. Additionally, the thicker the CMT in patients with EIFLs, the lower the reproducibility of the inner retinal layer thickness measurements.

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视网膜前膜内中央凹层异位患者各视网膜层厚度测量的可重复性。

背景:确定视网膜前膜(ERM)内中央凹层异位(eifl)患者各视网膜层厚度测量的可靠性。方法:将受试者分为有eifl的ERM患者(1组)和无eifl的ERM患者(2组)，测量视网膜层厚度2次，计算类内相关系数(ICC)和变异系数(CV)值。结果:1组神经纤维层(NFL)、神经节细胞层(GCL)、内丛状层(IPL)、内核层(INL)、外丛状层(OPL)、外核层(ONL)的CVs分别为22.39%、13.12%、13.37%、13.21%、15.09%、11.94%，ICCs分别为0.431、0.550、0.440、0.286、0.279、0.503。第2组的cv分别为18.20%、10.59%、10.65%、13.27%、14.75%和10.37%，ICCs分别为0.788、0.834、0.830、0.715、0.226和0.439。平均中央黄斑厚度(CMT)与NFL的cv呈显著相关(系数= 0.317;结论:与没有eifl的ERM患者相比，eifl患者视网膜内层厚度测量的可重复性较低。无论ERM患者是否存在eifl，包括OPL和ONL在内的视网膜外层厚度测量的再现性都很差。此外，eifs患者的CMT越厚，视网膜内层厚度测量的可重复性越低。

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来源期刊

Eye and Vision OPHTHALMOLOGY-

CiteScore

8.60

自引率

2.40%

发文量

审稿时长

15 weeks

期刊介绍： Eye and Vision is an open access, peer-reviewed journal for ophthalmologists and visual science specialists. It welcomes research articles, reviews, methodologies, commentaries, case reports, perspectives and short reports encompassing all aspects of eye and vision. Topics of interest include but are not limited to: current developments of theoretical, experimental and clinical investigations in ophthalmology, optometry and vision science which focus on novel and high-impact findings on central issues pertaining to biology, pathophysiology and etiology of eye diseases as well as advances in diagnostic techniques, surgical treatment, instrument updates, the latest drug findings, results of clinical trials and research findings. It aims to provide ophthalmologists and visual science specialists with the latest developments in theoretical, experimental and clinical investigations in eye and vision.