Protein post-translational modifications: A key factor in colorectal cancer resistance mechanisms

IF 2.6 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochimica et Biophysica Acta-Gene Regulatory Mechanisms Pub Date : 2023-08-23 DOI:10.1016/j.bbagrm.2023.194977

Bo Bi , Miaojuan Qiu , Peng Liu , Qiang Wang , Yingfei Wen , You Li , Binbin Li , Yongshu Li , Yulong He , Jing Zhao

{"title":"Protein post-translational modifications: A key factor in colorectal cancer resistance mechanisms","authors":"Bo Bi , Miaojuan Qiu , Peng Liu , Qiang Wang , Yingfei Wen , You Li , Binbin Li , Yongshu Li , Yulong He , Jing Zhao","doi":"10.1016/j.bbagrm.2023.194977","DOIUrl":null,"url":null,"abstract":"<div><p>Colorectal cancer (CRC) is one of the leading causes of cancer-related death. Despite advances in treatment, drug resistance remains a critical impediment. Post-translational modifications (PTMs) regulate protein stability, localization, and activity, impacting vital cellular processes. Recent research has highlighted the essential role of PTMs in the development of CRC resistance. This review summarizes recent advancements in understanding PTMs' roles in CRC resistance, focusing on the latest discoveries. We discuss the functional impact of PTMs on signaling pathways and molecules involved in CRC resistance, progress in drug development, and potential therapeutic targets. We also summarize the primary enrichment methods for PTMs. Finally, we discuss current challenges and future directions, including the need for more comprehensive PTM analysis methods and PTM-targeted therapies. This review identifies potential therapeutic interventions for addressing medication resistance in CRC, proposes prospective therapeutic options, and gives an overview of the function of PTMs in CRC resistance.</p></div>","PeriodicalId":55382,"journal":{"name":"Biochimica et Biophysica Acta-Gene Regulatory Mechanisms","volume":"1866 4","pages":"Article 194977"},"PeriodicalIF":2.6000,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochimica et Biophysica Acta-Gene Regulatory Mechanisms","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S187493992300072X","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related death. Despite advances in treatment, drug resistance remains a critical impediment. Post-translational modifications (PTMs) regulate protein stability, localization, and activity, impacting vital cellular processes. Recent research has highlighted the essential role of PTMs in the development of CRC resistance. This review summarizes recent advancements in understanding PTMs' roles in CRC resistance, focusing on the latest discoveries. We discuss the functional impact of PTMs on signaling pathways and molecules involved in CRC resistance, progress in drug development, and potential therapeutic targets. We also summarize the primary enrichment methods for PTMs. Finally, we discuss current challenges and future directions, including the need for more comprehensive PTM analysis methods and PTM-targeted therapies. This review identifies potential therapeutic interventions for addressing medication resistance in CRC, proposes prospective therapeutic options, and gives an overview of the function of PTMs in CRC resistance.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

蛋白质翻译后修饰：结直肠癌癌症耐药机制的关键因素

结直肠癌癌症（CRC）是导致癌症相关死亡的主要原因之一。尽管治疗取得了进展，但耐药性仍然是一个严重的障碍。翻译后修饰（PTMs）调节蛋白质的稳定性、定位和活性，影响重要的细胞过程。最近的研究强调了PTMs在CRC耐药性发展中的重要作用。这篇综述总结了在理解PTMs在CRC耐药性中的作用方面的最新进展，重点是最新发现。我们讨论了PTMs对参与CRC耐药性的信号通路和分子的功能影响、药物开发进展以及潜在的治疗靶点。我们还总结了PTMs的主要富集方法。最后，我们讨论了当前的挑战和未来的方向，包括需要更全面的PTM分析方法和PTM靶向治疗。这篇综述确定了解决CRC耐药性的潜在治疗干预措施，提出了前瞻性的治疗方案，并概述了PTMs在CRC耐药性中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Biochimica et Biophysica Acta-Gene Regulatory Mechanisms 生物-生化与分子生物学

CiteScore

9.20

自引率

2.10%

发文量

审稿时长

44 days

期刊介绍： BBA Gene Regulatory Mechanisms includes reports that describe novel insights into mechanisms of transcriptional, post-transcriptional and translational gene regulation. Special emphasis is placed on papers that identify epigenetic mechanisms of gene regulation, including chromatin, modification, and remodeling. This section also encompasses mechanistic studies of regulatory proteins and protein complexes; regulatory or mechanistic aspects of RNA processing; regulation of expression by small RNAs; genomic analysis of gene expression patterns; and modeling of gene regulatory pathways. Papers describing gene promoters, enhancers, silencers or other regulatory DNA regions must incorporate significant functions studies.