Reversible Calcineurin Inhibitor-associated Sensorimotor Polyneuropathy in a Lung Transplant Recipient: A Case Report.

IF 0.3 Q4 TRANSPLANTATION International Journal of Organ Transplantation Medicine Pub Date : 2021-01-01
T Antychin, J A Zarowski, V Verplancke, J M H Hendriks, S K Yogeswaran, P Lauwers, K Lamote, J M Kwakkel-van Erp
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引用次数: 0

Abstract

Calcineurin inhibitors (CNIs) are regarded as a corner stone in immunosuppressive therapy after solid organ transplantation. However, neurotoxicity is a common side effect of CNIs, resulting in a wide range of neurological symptoms such as headache, tremor and seizures. In this case report, we describe a patient who developed severe motor and sensory neuron dysfunction related to CNIs after bilateral lung transplantation, which resolved after halting CNI and switching to a mammalian Target of Rapamycin-inhibitor.

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可逆钙调磷酸酶抑制剂相关的感觉运动多发性神经病在肺移植受体:一个病例报告。
钙调磷酸酶抑制剂(CNIs)被认为是实体器官移植后免疫抑制治疗的基石。然而,神经毒性是CNIs的一个常见副作用,可导致广泛的神经系统症状,如头痛、震颤和癫痫发作。在本病例报告中,我们描述了一位患者,他在双侧肺移植后出现了与CNI相关的严重运动和感觉神经元功能障碍,在停止CNI并切换到哺乳动物靶向雷帕霉素抑制剂后,这种功能障碍得到了解决。
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来源期刊
CiteScore
1.60
自引率
0.00%
发文量
0
审稿时长
12 weeks
期刊介绍: The International Journal of Organ Transplantation Medicine (IJOTM) is a quarterly peer-reviewed English-language journal that publishes high-quality basic sciences and clinical research on transplantation. The scope of the journal includes organ and tissue donation, procurement and preservation; surgical techniques, innovations, and novelties in all aspects of transplantation; genomics and immunobiology; immunosuppressive drugs and pharmacology relevant to transplantation; graft survival and prevention of graft dysfunction and failure; clinical trials and population analyses in the field of transplantation; transplant complications; cell and tissue transplantation; infection; post-transplant malignancies; sociological and ethical issues and xenotransplantation.
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